Incomplete Functionalization of Glycodendrimers: Effects on Binding Affinity with Wheat Germ Agglutinin Takahiko Matsushita; Naomichi Toda; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
European Journal of Medicinal Chemistry Reports,
First page：100266,
Last page：100266, Apr. 2025
Elsevier BV, Scientific journal
DOI：https://doi.org/10.1016/j.ejmcr.2025.100266DOI ID：10.1016/j.ejmcr.2025.100266,
ISSN：2772-4174 Self-Assembly of Silole-Based Aggregation-Induced Emission Compounds with Green Fluorescent Protein under Physiological Conditions for Traceable and Versatile Drug Delivery. Miho Suzuki; Fumihiro Murakami; Md Shazadur Rahman; Yusuke Akui; Ken Hatano
ACS applied bio materials,
Volume：7,
Number：10,
First page：6477,
Last page：6491, Oct. 2024,
［International magazine］Biomacromolecules are viewed as promising drugs due to their specific functions in biological processes, biocompatibility, and pharmacological efficacy. Injective administration, chosen to avoid intestinal barriers, may in turn lead to immediate decay in the circulation system, unreliable targeting performance, or the induction of immune responses. For some biomacromolecules, chemically modified proteins have been developed for practical use. Various cargo or carrier systems are under development but have been delayed by technical difficulties. We present self-assembled nanocapsules with diameters ranging from 100 to 500 nm that can be deployed in physiological buffers to enclose various substances present in the buffers at the same time. Our amphiphilic nanocapsule, consisting of silole-core dendrimer products as the hydrophobic part and green fluorescent protein (GFP) derivatives as the hydrophilic part, connects and assembles spontaneously when mixed in solutions while engulfing dissolved or dispersed compounds together in a dose-dependent manner and shows unique optical characteristics because the dendrimer products exhibit aggregation-induced emission. Furthermore, the emission of the dendrimer causes considerable fluorescence resonance energy transfer (FRET) to GFP derivatives upon association. We could easily monitor assemblies by FRET states and particle sizes and have confirmed a stable presence in the buffer for at least a month. Further tracking of nanocapsules by fluorescence confirmed efficient uptake into some cancer cells. Nanocapsules based on GFP variants with or without a cell-surface-specific tag demonstrated that the tag improved the potential for specific targeted delivery. There were also indications that the nanocapsules became unstable after cellular uptake in the intracellular environment. We report here the simple preparation of traceable, stable, and biocompatible self-assembled nanocapsules as the basis for a versatile drug delivery system.
English, Scientific journal
DOI：https://doi.org/10.1021/acsabm.4c00639DOI ID：10.1021/acsabm.4c00639,
PubMed ID：39256188 Interpenetrating Polymer Network Capturing FRET-Sensitive Polymers Available for an Enzyme Assay Kota Miyairi; Hirokatsu Arai; Takahiko Matsushita; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
Biomacromolecules, Aug. 2024,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1021/acs.biomac.4c00622DOI ID：10.1021/acs.biomac.4c00622,
ORCID：164775308 Use of an oxazolidinone derivative of a sialyl thioglycoside as a useful glycosyl donor for α-favorable glycosidation with simple alcohols Jianhong Zhang; Tetsuo Koyama; Takahiko Matsushita; Ken Hatano; Koji Matsuoka
Tetrahedron Letters, Aug. 2024,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.tetlet.2024.155189DOI ID：10.1016/j.tetlet.2024.155189,
ORCID：163137912 Preparation of fluorogenic glycopolymers having mannose moieties that can be used for determining the affinity of lectins by means of intermolecular FRET Kota Miyairi; Takahiko Matsushita; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
Journal of Molecular Structure, Jun. 2024,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.molstruc.2024.137896DOI ID：10.1016/j.molstruc.2024.137896,
ISSN：0022-2860,
ORCID：162952645 pH-Dependent proteolytic activity of histidine-pendant polyacrylamides Shinzo Omiya; Hinako Yamochi; Tetsuo Koyama; Ken Hatano; Koji Matsuoka; Takahiko Matsushita
European Polymer Journal, Apr. 2024,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.eurpolymj.2024.112898DOI ID：10.1016/j.eurpolymj.2024.112898,
ISSN：0014-3057,
ORCID：162952627 Preparation of a water-soluble polymer having pheophorbide a side chains using glycopolymer assembly Koji Matsuoka; Jyuichi Nakada; Masataka Nakazato; Takahiko Matsushita; Tetsuo Koyama; Ken Hatano
Tetrahedron Letters, Mar. 2024,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.tetlet.2024.154963DOI ID：10.1016/j.tetlet.2024.154963,
ISSN：0040-4039,
ORCID：162952664 Synthetic assembly of α-O-linked-type GlcNAc using polymer chemistry affords sugar clusters, which effectively bind to lectins Jyuichi Nakada; Takahiko Matsushita; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
Bioorganic & Medicinal Chemistry Letters, Feb. 2024,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.bmcl.2024.129616DOI ID：10.1016/j.bmcl.2024.129616,
ISSN：0960-894X,
ORCID：162952363 Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin Takahiko Matsushita; Momoka Nozaki; Mio Sunaga; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
ACS Omega, Oct. 2023,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1021/acsomega.3c05151DOI ID：10.1021/acsomega.3c05151,
ISSN：2470-1343,
ORCID：162952808 Preparation of a Water-Soluble Glycopolymer Bearing Porphyrin Skeletons and Its Biological Properties Yoshihiro Ishimaru; Tomohide Moteki; Miho Suzuki; Tetsuo Koyama; Takahiko Matsushita; Ken Hatano; Koji Matsuoka
ACS Omega, Oct. 2023,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1021/acsomega.3c05581DOI ID：10.1021/acsomega.3c05581,
ISSN：2470-1343,
ORCID：162953065 Proteolytic polymer: polyacrylamides functionalized with amino acids cleave bovine and human serum albumins Takahiko Matsushita; Hinako Yamochi; Shinzo Omiya; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
Bioorganic & Medicinal Chemistry,
Volume：92,
First page：117422,
Last page：117422, Sep. 2023
Elsevier BV, Scientific journal
DOI：https://doi.org/10.1016/j.bmc.2023.117422DOI ID：10.1016/j.bmc.2023.117422,
ISSN：0968-0896 Synthetic assembly of a series of glycopolymers having sialyl α2-3 lactose moieties connected with longer spacer arms Ryota Adachi; Takahiko Matsushita; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
Bioorganic & Medicinal Chemistry,
Volume：81,
First page：117209,
Last page：117209, Mar. 2023,
[Reviewed]Elsevier {BV}, English, Scientific journal
DOI：https://doi.org/10.1016/j.bmc.2023.117209DOI ID：10.1016/j.bmc.2023.117209,
ISSN：0968-0896,
ORCID：129064751 Dendritic maleimide-thiol adducts carrying pendant glycosides as high-affinity ligands Takahiko Matsushita; Naomichi Toda; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
Bioorganic Chemistry,
Volume：128,
First page：106061,
Last page：106061, Nov. 2022
Elsevier BV, Scientific journal
DOI：https://doi.org/10.1016/j.bioorg.2022.106061DOI ID：10.1016/j.bioorg.2022.106061,
ISSN：0045-2068 Chemical modification of CNN 1. Complete protection of CNN Koji Matsuoka; Daiki Endo; Ryota Adachi; Tetsuo Koyama; Takahiko Matsushita; Ken Hatano
Tetrahedron Letters,
Volume：103,
First page：153986,
Last page：153986, Aug. 2022
Elsevier {BV}, English, Scientific journal
DOI：https://doi.org/10.1016/j.tetlet.2022.153986DOI ID：10.1016/j.tetlet.2022.153986,
ISSN：0040-4039,
ORCID：116408632 Quick and ultra-sensitive digital assay of influenza virus using sub-picoliter microwells. Hiroki Ashiba; Masato Yasuura; Takashi Fukuda; Ken Hatano; Makoto Fujimaki
Analytica chimica acta,
Volume：1213,
First page：339926,
Last page：339926, Jun. 2022,
［International magazine］Quick and sensitive virus detection methods have been developed using sub-picoliter microwells. One method uses an aggregation-induced emission (AIE) reagent, and the other uses an enzymatic reaction supported with immunomagnetic beads at a high concentration of 108 particles/mL. Examination of influenza A virus detection using the AIE reagent exhibited a detection limit of 3 × 105 copies/mL, which was achievable within 1 min of the total measurement time. The high-concentration immunomagnetic beads method exhibited a detection limit as low as 1 × 102 copies/mL. The developed methods are effective and practical tools for ultrafast and ultrasensitive virus detection.
English, Scientific journal
DOI：https://doi.org/10.1016/j.aca.2022.339926DOI ID：10.1016/j.aca.2022.339926,
PubMed ID：35641063 Systematic synthesis of a series of glycopolymers having N-acetyl-D-glucosamine moieties that can be used for evaluations of lectin—carbohydrate interactions Koji Matsuoka; Masaki Nakagawa; Tetsuo Koyama; Takahiko Matsushita; Ken Hatano
European Polymer Journal,
Volume：168,
First page：111101,
Last page：111101, Apr. 2022
Elsevier BV, Scientific journal
DOI：https://doi.org/10.1016/j.eurpolymj.2022.111101DOI ID：10.1016/j.eurpolymj.2022.111101,
ISSN：0014-3057 Preparation of glycopolymers having sialyl α2 → 3 lactose moieties as the potent inhibitors for mumps virus Koji Matsuoka; Takayuki Kaneshima; Ryota Adachi; Jiei Sasaki; Takao Hashiguchi; Tetsuo Koyama; Takahiko Matsushita; Ken Hatano
Bioorganic & Medicinal Chemistry Letters,
Volume：52,
First page：128389,
Last page：128389, Nov. 2021
Elsevier BV, Scientific journal
DOI：https://doi.org/10.1016/j.bmcl.2021.128389DOI ID：10.1016/j.bmcl.2021.128389,
ISSN：0960-894X Preparation of lauryl thioglycoside of N-glycolylneuraminic acid (Neu5Gc) as a useful glycosyl donor for assembly of an oligosaccharide containing Neu5Gc Jianhong Zhang; Tetsuo Koyama; Takahiko Matsushita; Ken Hatano; Koji Matsuoka
Tetrahedron Letters,
Volume：83,
First page：153403,
Last page：153403, Oct. 2021
Elsevier BV, Scientific journal
DOI：https://doi.org/10.1016/j.tetlet.2021.153403DOI ID：10.1016/j.tetlet.2021.153403,
ISSN：0040-4039 Controlled release of molasses melanoidin-like product from hybrid organic-inorganic silica xerogels and its application to the phytoextraction of lead through the Indian mustard Ken-ichi Hatano; Minori Teraki; Daiki Nakajima; Takeshi Yamatsu
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,
Volume：28,
Number：28,
First page：37562,
Last page：37569, Jul. 2021
English, Scientific journal
DOI：https://doi.org/10.1007/s11356-021-13363-1DOI ID：10.1007/s11356-021-13363-1,
ISSN：0944-1344,
eISSN：1614-7499,
Web of Science ID：WOS:000628491500008 Verification of suitable ratio of carbohydrate residues in a glycopolymer having GlcNAc moieties for determining the affinity for wheat germ agglutinin Koji Matsuoka; Shohei Yamashita; Tetsuo Koyama; Takahiko Matsushita; Ken Hatano
Journal of Molecular Structure,
Volume：1217,
First page：128404,
Last page：128404, Oct. 2020
Elsevier BV, Scientific journal
DOI：https://doi.org/10.1016/j.molstruc.2020.128404DOI ID：10.1016/j.molstruc.2020.128404,
ISSN：0022-2860 Fluorogenic glycopolymers available for determining the affinity of lectins by intermolecular FRET Koji Matsuoka; Yuya Suzuki; Tetsuo Koyama; Takahiko Matsushita; Ken Hatano
Bioorganic & Medicinal Chemistry Letters,
Volume：30,
Number：8,
First page：127024,
Last page：127024, Apr. 2020
Elsevier BV, Scientific journal
DOI：https://doi.org/10.1016/j.bmcl.2020.127024DOI ID：10.1016/j.bmcl.2020.127024,
ISSN：0960-894X Neuraminidase-triggered activation of prodrug-type substrate of 4-nitroaniline Takahiko Matsushita; Monique Nami Danyel; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
Bioorganic & Medicinal Chemistry Letters,
Volume：30,
Number：2,
First page：126883,
Last page：126883, Jan. 2020
Elsevier BV, Scientific journal
DOI：https://doi.org/10.1016/j.bmcl.2019.126883DOI ID：10.1016/j.bmcl.2019.126883,
ISSN：0960-894X Simultaneous suppression of magnetic nanoscale powder and fermented bark amendment for arsenic and cadmium uptake by radish sprouts grown in agar medium Xiaotong Sun; Huijiao Mo; Ken-ichi Hatano; Hideyuki Itabashi; Masanobu Mori
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,
Volume：26,
Number：14,
First page：14483,
Last page：14493, May 2019
English, Scientific journal
DOI：https://doi.org/10.1007/s11356-019-04756-4DOI ID：10.1007/s11356-019-04756-4,
ISSN：0944-1344,
eISSN：1614-7499,
Web of Science ID：WOS:000466906000073 A constraint scaffold enhances affinity of a bivalent N-acetylglucosamine ligand against wheat germ agglutinin Takahiko Matsushita; Koji Tsuchibuchi; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
Bioorganic & Medicinal Chemistry Letters,
Volume：28,
Number：10,
First page：1704,
Last page：1707, Apr. 2018,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.bmcl.2018.04.047DOI ID：10.1016/j.bmcl.2018.04.047 Iodoacetyl-functionalized pullulan: A supplemental enhancer for single-domain antibody-polyclonal antibody sandwich enzyme-linked immunosorbent assay for detection of survivin Takahiko Matsushita; Hidenao Arai; Tetsuo Koyama; Ken Hatano; Naoto Nemoto; Koji Matsuoka
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
Volume：27,
Number：21,
First page：4844,
Last page：4848, Nov. 2017,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.bmcl.2017.09.045DOI ID：10.1016/j.bmcl.2017.09.045,
ISSN：0960-894X,
eISSN：1464-3405,
ORCID：37252279,
Web of Science ID：WOS:000413998900013 Synthetic Assembly of Mannose Moieties Using Polymer Chemistry and the Biological Evaluation of Its Interaction towards Concanavalin A Deepti Diwan; Kohei Shinkai; Toshihiro Tetsuka; Bin Cao; Hidenao Arai; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
MOLECULES,
Volume：22,
Number：1, Jan. 2017,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.3390/molecules22010157DOI ID：10.3390/molecules22010157,
ISSN：1420-3049,
ORCID：41456981,
Web of Science ID：WOS:000395473500154 Synthetic assembly of novel avidin-biotin-GlcNAc (ABG) complex as an attractive bio-probe and its interaction with wheat germ agglutinin (WGA) Amrita Kumari; Tetsuo Koyama; Ken Hatano; Koji Matsuoka
BIOORGANIC CHEMISTRY,
Volume：68,
First page：219,
Last page：225, Oct. 2016,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.bioorg.2016.08.002DOI ID：10.1016/j.bioorg.2016.08.002,
ISSN：0045-2068,
eISSN：1090-2120,
ORCID：41456984,
Web of Science ID：WOS:000387978400022 Triphenylphosphinecarboxamide: An Effective Reagent for the Reduction of Azides and Its Application to Nucleic Acid Detection Hisao Saneyoshi; Tatsuya Ochikubo; Takushi Mashimo; Ken Hatano; Yoshihiro Ito; Hiroshi Abe
ORGANIC LETTERS,
Volume：16,
Number：1,
First page：30,
Last page：33, Jan. 2014,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1021/ol402832wDOI ID：10.1021/ol402832w,
ISSN：1523-7060,
eISSN：1523-7052,
Web of Science ID：WOS:000329472800009 Use of chloromethylstyrene as a supporter for convenient preparation of carbohydrate monomer and glycopolymers Matsuoka Koji; Kurita Anna; Koyama Tetsuo; Hatano Ken
Carbohydrate Polymers,
Volume：107,
First page：209,
Last page：213, 2014,
[Reviewed]DOI：https://doi.org/10.1016/j.carbpol.2014.01.104DOI ID：10.1016/j.carbpol.2014.01.104,
ORCID：41456992,
Web of Science ID：WOS:000335103900027 Synthesis of chiral dopants based on carbohydrates Tsuruta Toru; Koyama Tetsuo; Yasutake Mikio; Hatano Ken; Matsuoka Koji
Carbohydrate Research,
Volume：393,
First page：15,
Last page：22, 2014,
[Reviewed]DOI：https://doi.org/10.1016/j.carres.2014.04.007DOI ID：10.1016/j.carres.2014.04.007,
ORCID：41456991,
Web of Science ID：WOS:000338714300003 Synthesis and Influenza Virus Inhibitory Activities of Carbosilane Dendrimers Peripherally Functionalized with Hemagglutinin-Binding Peptide Hatano Ken; Matsubara Teruhiko; Muramatsu Yosuke; Ezure Masakazu; Koyama Tetsuo; Matsuoka Koji; Kuriyama Ryunosuke; Kori Haruka; Sato Toshinori
Journal of Medicinal Chemistry,
Volume：57,
Number：20,
First page：8332,
Last page：8339, 2014,
[Reviewed]DOI：https://doi.org/10.1021/jm5007676DOI ID：10.1021/jm5007676,
ORCID：41456989,
Web of Science ID：WOS:000343740700011 Synthesis and Structural Revision of a Brominated Sesquiterpenoid, Aldingenin C Takahashi Shunya; Yasuda Masayuki; Nakamura Takemichi; Hatano Ken; Matsuoka Koji; Koshino Hiroyuki
Journal of Organic Chemistry,
Volume：79,
Number：19,
First page：9373,
Last page：9380, 2014,
[Reviewed]DOI：https://doi.org/10.1021/jo501228vDOI ID：10.1021/jo501228v,
ORCID：40436750,
Web of Science ID：WOS:000342719600044 Improved Signal-to-Noise Ratio of Green-Sensitive Organic Photoconductive Device by Doping Silole Derivative Takeshi Fukuda; Sho Kimura; Norihiko Kamata; Keita Mori; Ken Hatano
MOLECULAR CRYSTALS AND LIQUID CRYSTALS,
Volume：578,
Number：1,
First page：119,
Last page：126, Sep. 2013,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1080/15421406.2013.804784DOI ID：10.1080/15421406.2013.804784,
ISSN：1542-1406,
eISSN：1563-5287,
Web of Science ID：WOS:000323813500019 Synthesis of a nucleoside phosphorodithioate analogue responsive to microenvironmental changes through chiral induction Hisao Saneyoshi; Takushi Mashimo; Ken Hatano; Yoshihiro Ito; Hiroshi Abe
TETRAHEDRON LETTERS,
Volume：54,
Number：9,
First page：1080,
Last page：1083, Feb. 2013,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.tetlet.2012.12.028DOI ID：10.1016/j.tetlet.2012.12.028,
ISSN：0040-4039,
Web of Science ID：WOS:000315063700010 Convenient assembly of trimeric Le(x) determinants using carbosilane scaffolds by means of Huisgen cycloaddition Koji Matsuoka; Hiroki Yamaguchi; Tatsuya Kohzu; Jun-Ichi Sakamoto; Tetsuo Koyama; Ken Hatano; Shigeto Yamamoto; Tsutomu Mori; Kenichi Hatanaka
TETRAHEDRON LETTERS,
Volume：53,
Number：50,
First page：6793,
Last page：6796, Dec. 2012,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.tetlet.2012.10.004DOI ID：10.1016/j.tetlet.2012.10.004,
ISSN：0040-4039,
ORCID：41457001,
Web of Science ID：WOS:000311473500016 Improved optical-to-electrical conversion efficiency by doping silole derivative with low ionization potential Takeshi Fukuda; Sho Kimura; Zentaro Honda; Norihiko Kamata; Keita Mori; Ken Hatano
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE,
Volume：209,
Number：11,
First page：2324,
Last page：2329, Nov. 2012,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1002/pssa.201228242DOI ID：10.1002/pssa.201228242,
ISSN：1862-6300,
Web of Science ID：WOS:000313729800040 A carbosilane dendrimer and a silacyclopentadiene analog carrying peripheral lactoses as drug-delivery systems Hiroaki Aizawa; Kentaro Otomo; Nobuaki Honsho; Tomoyuki Shimazaki; Masumi Villeneuve; Koji Matsuoka; Ken Hatano; Daiyo Terunuma
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
Volume：22,
Number：10,
First page：3564,
Last page：3566, May 2012,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.bmcl.2012.03.034DOI ID：10.1016/j.bmcl.2012.03.034,
ISSN：0960-894X,
ORCID：41456999,
Web of Science ID：WOS:000303545900035 Lectin Detection Based on the Aggregation-Induced Emission Effect Ken Hatano; Koji Matsuoka; Daiyo Terunuma
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY,
Volume：24,
Number：136,
First page：78,
Last page：94, Mar. 2012,
[Reviewed]English
DOI：https://doi.org/10.4052/tigg.24.78DOI ID：10.4052/tigg.24.78,
ISSN：0915-7352,
ORCID：41457005,
Web of Science ID：WOS:000305623400003 Synthetic Assembly of Bifluorescence-Labeled Glycopolymers as Substrates for Assaying alpha-Amylase by Resonance Energy Transfer Koji Matsuoka; Hirokatsu Arai; Hiroyuki Oka; Tetsuo Koyama; Ken Hatano
ACS MACRO LETTERS,
Volume：1,
Number：2,
First page：266,
Last page：269, Feb. 2012,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1021/mz200135yDOI ID：10.1021/mz200135y,
ISSN：2161-1653,
ORCID：41457007,
Web of Science ID：WOS:000301969500003 Doping Effect of Silole Derivative in Coumarin 30 Photoconductive Film Toshikatsu Sakai; Hokuto Seo; Satoshi Aihara; Misao Kubota; Norifumi Egami; Keita Mori; Takeshi Fukuda; Ken Hatano; Norihiko Kamata
MOLECULAR CRYSTALS AND LIQUID CRYSTALS,
Volume：568,
First page：74,
Last page：81, 2012,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1080/15421406.2012.710188DOI ID：10.1080/15421406.2012.710188,
ISSN：1542-1406,
Web of Science ID：WOS:000309285500012 Doping Effect of Ethylcarbazole-Contained-Silole in Blue-Sensitive Organic Photoconductive Device Sho Kimura; Takeshi Fukuda; Zentaro Honda; Norihiko Kamata; Keita Mori; Ken Hatano
MOLECULAR CRYSTALS AND LIQUID CRYSTALS,
Volume：566,
First page：54,
Last page：60, 2012,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1080/15421406.2012.701120DOI ID：10.1080/15421406.2012.701120,
ISSN：1542-1406,
eISSN：1563-5287,
Web of Science ID：WOS:000308766800010 Synthetic studies of bi-fluorescence-labeled maltooligosaccharides as substrates for alpha-amylase on the basis of fluorescence resonance energy transfer (FRET) Oka Hiroyuki; Koyama Tetsuo; Hatano Ken; Matsuoka Koji
Bioorganic & Medicinal Chemistry,
Volume：20,
Number：1,
First page：435,
Last page：445, 2012,
[Reviewed]DOI：https://doi.org/10.1016/j.bmc.2011.10.065DOI ID：10.1016/j.bmc.2011.10.065,
ORCID：41457008,
Web of Science ID：WOS:000298633300047 Synthesis and biological evaluation of sialic acid derivatives containing a long hydrophobic chain at the anomeric position and their C-5 linked polymers as potent influenza virus inhibitors Suzuki Kaori; Koyama Tetsuo; Yingsakmongkon Sangchai; Suzuki Yasuo; Hatano Ken; Matsuoka Koji
Bioorganic & Medicinal Chemistry,
Volume：20,
Number：1,
First page：446,
Last page：454, 2012,
[Reviewed]DOI：https://doi.org/10.1016/j.bmc.2011.10.064DOI ID：10.1016/j.bmc.2011.10.064,
ORCID：41457006,
Web of Science ID：WOS:000298633300048 その場で診断できる感染症検査薬をめざして(レーダー) 幡野 健; 松岡 浩司
Volume：59,
Number：11,
First page：560,
Last page：561, 2011
Japanese
DOI：https://doi.org/10.20665/kakyoshi.59.11_560DOI ID：10.20665/kakyoshi.59.11_560,
ISSN：0386-2151,
CiNii Articles ID：110008898224,
CiNii Books ID：AN10033386 Ultrafast study of charge generation in silole:fluorene mixed film for color selective organic photoconductive device Takeshi Fukuda; Ryohei Kobayashi; Zentaro Honda; Norihiko Kamata; Keita Mori; Yuu Suzuki; Ken Hatano; Akihiro Furube
PHYSICA STATUS SOLIDI C: CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 8, NO 2,
Volume：8,
Number：2, 2011,
[Reviewed]English, International conference proceedings
DOI：https://doi.org/10.1002/pssc.201000454DOI ID：10.1002/pssc.201000454,
ISSN：1862-6351,
Web of Science ID：WOS:000301533800113 Synthesis of sialyllactosamine clusters using carbosilane as core scaffolds by means of chemical and enzymatic approaches Koji Matsuoka; Reina Kaneko; Tetsuo Koyama; XiaoTao Ma; Yasuaki Esumi; Takemichi Nakamura; Ken Hatano; Daiyo Terunuma
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
Volume：20,
Number：16,
First page：4906,
Last page：4910, Aug. 2010,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.bmcl.2010.06.066DOI ID：10.1016/j.bmcl.2010.06.066,
ISSN：0960-894X,
ORCID：41457011,
Web of Science ID：WOS:000280348400038 Synthetic construction of a fucosyl chitobiose as an allergen-associated carbohydrate epitope and the glycopolymer involving highly clustered trisaccharidic sequences Koji Matsuoka; Hiroki Yamaguchi; Tetsuo Koyama; Ken Hatano; Daiyo Terunuma
TETRAHEDRON LETTERS,
Volume：51,
Number：18,
First page：2529,
Last page：2532, May 2010,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.tetlet.2010.03.004DOI ID：10.1016/j.tetlet.2010.03.004,
ISSN：0040-4039,
ORCID：41457012,
Web of Science ID：WOS:000276972200039 Simple and conveniently accessible bi-fluorescence-labeled substrates for amylases Hiroyuki Oka; Tetsuo Koyama; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
Volume：20,
Number：6,
First page：1969,
Last page：1971, Mar. 2010,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.bmcl.2010.01.117DOI ID：10.1016/j.bmcl.2010.01.117,
ISSN：0960-894X,
ORCID：41457010,
Web of Science ID：WOS:000275221500038 Analytical investigations of the behavior of silole-core dendrimers with peripheral globotriaose in water and acetone/water mixed solvent Hiroaki Aizawa; Ken Hatano; Hitoshi Saeki; Nobuaki Honsho; Tetsuo Koyama; Koji Matsuoka; Daiyo Terunuma
TETRAHEDRON LETTERS,
Volume：51,
Number：12,
First page：1545,
Last page：1549, Mar. 2010,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.tetlet.2010.01.041DOI ID：10.1016/j.tetlet.2010.01.041,
ISSN：0040-4039,
ORCID：41457009,
Web of Science ID：WOS:000275552000004 Improved Photoconductive Characteristics of Solution-Processed Organic Device by Doping Silole Derivative Ryohei Kobayashi; Takeshi Fukuda; Yuu Suzuki; Ken Hatano; Norihiko Kamata; Satoshi Aihara; Hokuto Seo; Daiyo Terunuma
MOLECULAR CRYSTALS AND LIQUID CRYSTALS,
Volume：519,
First page：206,
Last page：212, 2010,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1080/15421401003594719DOI ID：10.1080/15421401003594719,
ISSN：1542-1406,
Web of Science ID：WOS:000277664700030 Relapsing fever Borrelia binds to neolacto glycans and mediates rosetting of human erythrocytes Betty P. Guo; Susann Teneberg; Robert Munch; Daiyo Terunuma; Ken Hatano; Koji Matsuoka; Jonas Angstrom; Thomas Boren; Sven Bergstrom
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
Volume：106,
Number：46,
First page：19280,
Last page：19285, Nov. 2009,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1073/pnas.0905470106DOI ID：10.1073/pnas.0905470106,
ISSN：0027-8424,
ORCID：41457015,
Web of Science ID：WOS:000271907400013 Fluorescence quenching detection of peanut agglutinin based on photoluminescent silole-core carbosilane dendrimer peripherally functionalized with lactose Ken Hatano; Hitoshi Saeki; Hiroo Yokota; Hiroaki Aizawa; Tetsuo Koyama; Koji Matsuoka; Daiyo Terunuma
TETRAHEDRON LETTERS,
Volume：50,
Number：42,
First page：5816,
Last page：5819, Oct. 2009,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.tetlet.2009.07.153DOI ID：10.1016/j.tetlet.2009.07.153,
ISSN：0040-4039,
ORCID：41457014,
Web of Science ID：WOS:000269967500013 Synthesis of sialic acid derivatives having a C = C double bond substituted at the C-5 position and their glycopolymers Kaori Suzuki; Jun-Ichi Sakamoto; Tetsuo Koyama; Sangchai Yingsakmongkon; Yasuo Suzuki; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
Volume：19,
Number：17,
First page：5105,
Last page：5108, Sep. 2009,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.bmcl.2009.07.034DOI ID：10.1016/j.bmcl.2009.07.034,
ISSN：0960-894X,
ORCID：41457018,
Web of Science ID：WOS:000268863800048 Syntheses and biological evaluations of carbosilane dendrimers uniformly functionalized with sialyl alpha(2 -> 3) lactose moieties as inhibitors for human influenza viruses Hiroyuki Oka; Tomotsune Onaga; Tetsuo Koyama; Chao-Tan Guo; Yasuo Suzuki; Yasuaki Esumi; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
BIOORGANIC & MEDICINAL CHEMISTRY,
Volume：17,
Number：15,
First page：5465,
Last page：5475, Aug. 2009,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1016/j.bmc.2009.06.035DOI ID：10.1016/j.bmc.2009.06.035,
ISSN：0968-0896,
ORCID：41457016,
Web of Science ID：WOS:000268099700013 Highly luminescent glycocluster: silole-core carbosilane dendrimer having peripheral globotriaose Hatano Ken; Aizawa Hiroaki; Yokota Hiroo; Yamada Akihiro; Esumi Yasuaki; Koshino Hiroyuki; Koyama Tetsuo; Matsuoka Koji; Terunuma Daiyo
Tetrahedron Letters,
Volume：48,
Number：25,
First page：4365,
Last page：4368, 2007,
[Reviewed]DOI：https://doi.org/10.1016/j.tetlet.2007.04.100DOI ID：10.1016/j.tetlet.2007.04.100,
ORCID：40436946,
Web of Science ID：WOS:000247278100012 A highly-luminescent glycocluster in water: Silole-core carbosilane dendrimer having peripheral globotriaose
Ken Hatano; Hiroaki Aizawa; Hiroo Yokota; Koji Matsuoka; Daiyo Terunuma
Polymer Preprints, Japan, Volume：55, Number：2, First page：3007, Last page：3008, 2006
Japanese, International conference proceedings
SCOPUS ID：33846133700
Synthetic studies of high-density-type glycopolymers (2)
Tetsuo Koyama; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
Polymer Preprints, Japan, Volume：55, Number：1, First page：2088, 2006
Japanese, International conference proceedings
SCOPUS ID：33749851551
Synthetic studies of novel water-soluble glycopolymers having sialic acid moieties (I)
Chiharu Takita; Jun-Ichi Sakamoto; Tetsuo Koyama; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
Polymer Preprints, Japan, Volume：55, Number：1, First page：2087, 2006
Japanese, International conference proceedings
SCOPUS ID：33749823326
Identification and characterization of carbohydrate molecules in mammalian cells recognized by dengue virus type 2. Chie Aoki; Kazuya I.P.J. Hidari; Saki Itonori; Akihiro Yamada; Naonori Takahashi; Takeshi Kasama; Futoshi Hasebe; Mohammend Alimul Islam; Ken Hatano; Koji Matsuoka; Takao Taki; Chao-Tan Guo; Tadanobu Takahashi; Yuichi Sakano; Takashi Suzuki; Daisei Miyamoto; Mutsumi Sugita; Daiyo Terunuma; Koichi Morita; Yasuo Suzuki
J. Biochem.,
Volume：139,
First page：607,
Last page：614, 2006,
[Reviewed]English, Scientific journal
DOI：https://doi.org/10.1093/jb/mvj067DOI ID：10.1093/jb/mvj067 Syntheses and Vero toxin-binding activities of carbosilane dendrimers periphery-functionalized with galabiose Yamada Akihiro; Hatano Ken; Matsuoka Koji; Koyama Tetsuo; Esumi Yasuaki; Koshino Hiroyuki; Hino Kumiko; Nishikawa Kiyotaka; Natori Yasuhiro; Terunuma Daiyo
Tetrahedron,
Volume：62,
Number：21,
First page：5074,
Last page：5083, 2006,
[Reviewed]DOI：https://doi.org/10.1016/j.tet.2006.03.042DOI ID：10.1016/j.tet.2006.03.042,
ORCID：40436966,
Web of Science ID：WOS:000237485300006 Crystallization and preliminary X-ray analysis of the YjgF/YER057c/UK114-family protein ST0811 from Sulfolobus tokodaii strain 7.
Takuya Miyakawa; Ken Ichi Hatano; Woo Cheol Lee; Yusuke Kato; Yoriko Sawano; Fumiaki Yumoto; Koji Nagata; Masaru Tanokura
Acta crystallographica. Section F, Structural biology and crystallization communications, Volume：61, Number：Pt 9, First page：828, Last page：30, Sep. 2005, ［International magazine］
ST0811 from Sulfolobus tokodaii strain 7, a member of the YjgF/YER057c/UK114 protein family, was crystallized by the sitting-drop vapour-diffusion method using PEG 10,000 as precipitant. The crystals diffracted X-rays to beyond 2.0 A resolution using an in-house rotating-anode generator. The crystals belonged to the rhombohedral space group R3, with hexagonal unit-cell parameters a = b = 55.0, c = 223.2 A. The crystals contained two molecules in the asymmetric unit (VM = 2.3 A3 Da(-1)) and had a solvent content of 47%.
English, Scientific journal
eISSN：1744-3091, PubMed ID：16511170, PubMed Central ID：PMC1978107
Synthetic studies of high-density-type glycopolymers.-Driving for developing effecient Vero-toxin neutlizer
Tetsuo Koyama; Yusuke Goshu; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
Polymer Preprints, Japan, Volume：54, Number：1, First page：2173, 2005
Japanese, International conference proceedings
SCOPUS ID：33645651591
Synthetic studies of carbosilane dendrimers functionalized with sugar moieties (IX) - Skelton effect on biological assay of lacto-n-neotetraose culsters as dengue virus inhibitory
Akihiro Yamada; Ken Hatano; Koji Matsuoka; Yasuaki Esumi; Chie Aoki; Kazuya Hidari; Yasuo Suzuki; Daiyo Terunuma
Polymer Preprints, Japan, Volume：54, Number：1, First page：2127, 2005
Japanese, International conference proceedings
SCOPUS ID：33645645777
Synthetic studies of sugar - Amino acid hybrid polymers(1)
Yusuke Goshu; Tetsuo Koyama; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
Polymer Preprints, Japan, Volume：54, Number：1, First page：2174, 2005
Japanese, International conference proceedings
SCOPUS ID：33645634507
Synthesis and characterization of new soluble Polydiphenylsilane derivatives
Toshiyuki Sato; Ken Hatano; Norihiko Kamata; Koji Matsuoka; Daiyo Terunuma
Polymer Preprints, Japan, Volume：54, Number：1, First page：337, 2005
Japanese, International conference proceedings
SCOPUS ID：33645575319
Syntheses of new polysilanes bearing pendant liquid-crystalline molecules (II)
Hideki Takahashi; Ken Hatano; Yoshio Aoki; Koji Matsuoka; Norihiko Kamata; Daiyo Terunuma
Polymer Preprints, Japan, Volume：54, Number：1, First page：443, 2005
Japanese, International conference proceedings
SCOPUS ID：33645572418
The First Examples of Stable Benzenes Fused with Two Three-membered Rings : Synthesis and Structures of the Two Stereoisomers of Bis(silacyclopropa)benzenes TAJIMA Tomoyuki; HATANO Ken; SASAKI Takayo; SASAMORI Takahiro; TAKEDA Nobuhiro; TOKITOH Norihiro
Chemistry Letters,
Volume：32,
Number：3,
First page：220,
Last page：221, Mar. 2003
Two stereoisomers of the first stable bis(silacyclopropa)benzenes (
1a,
1b) were successfully synthesized by the reaction of Tbt(Dip)SiLi
2 (
3) [Tbt = 2,4,6-tris[bis(trimethylsilyl)methyl]phenyl, Dip = 2,6-diisopropylphenyl] with 1,2,4,5-tetrabromobenzene. The molecular structures of
1a and
1b were discussed on the basis of the X-ray structural analyses.
The Chemical Society of Japan, English
DOI：https://doi.org/10.1246/cl.2003.220DOI ID：10.1246/cl.2003.220,
ISSN：0366-7022,
CiNii Articles ID：10012814431,
CiNii Books ID：AA00603318 Generation and Reactions of an Overcrowded Diaryldilithiosilane TOKITOH Norihiro; HATANO Ken; SADAHIRO Tomoyuki; OKAZAKI Renji
Chemistry Letters,
Volume：1999,
Number：9,
First page：931,
Last page：932, Sep. 1999
Exhaustive reduction of dibromo(2,6-diisopropylphenyl){2,4,6-tris[bis(trimethylsilyl)methyl]phenyl}silane with excess amount of lithium naphthalenide (more than 4 molar amounts) in tetrahydrofuran at −78 °C gave the corresponding dilithiosilane, the effective formation of which was confirmed by the trapping experiments with a variety of electrophiles. The diaryldilithiosilane thus generated was found to be stable at −78 °C but undergo an intramolecular proton abstraction to give the lithium-migrated dilithiosilane.
1The Chemical Society of Japan, English
DOI：https://doi.org/10.1246/cl.1999.931DOI ID：10.1246/cl.1999.931,
ISSN：0366-7022,
CiNii Articles ID：10005718412,
CiNii Books ID：AA00603318
Carbosilane glycodendrimers Ken Hatano; Koji Matsuoka; Daiyo Terunuma
Chemical Society Reviews,
Volume：42,
Number：11,
First page：4574,
Last page：4598, 07 Jun. 2013
English, Book review
DOI：https://doi.org/10.1039/c2cs35421gDOI ID：10.1039/c2cs35421g,
ISSN：0306-0012,
PubMed ID：23257960,
SCOPUS ID：84877819735 Glyco-silicon functional materials as anti-influenza virus agents Koji Matsuoka; Tetsuo Koyama; Ken Hatano
Open Glycoscience,
Volume：5,
Number：1,
First page：31,
Last page：40, 2012
English, Book review
DOI：https://doi.org/10.2174/1875398101205010031DOI ID：10.2174/1875398101205010031,
ISSN：1875-3981,
SCOPUS ID：84861876640 Development of multitasking biosensor for bacteria and viruses based on glyco-cluster effect
幡野 健; 松岡 浩司
Bio industry, Volume：28, Number：3, First page：55, Last page：59, Mar. 2011
Japanese
ISSN：0910-6545, CiNii Articles ID：40018715008, CiNii Books ID：AN10039203
Novel synthetic method to attach functional sugar chains on gold-nanoparticles小山 哲夫; 幡野 健; 松岡 浩司
Volume：3,
First page：49,
Last page：49, 2011
Multivalent structure with carbohydrate moieties and its biological properties have been studied. Novel method for synthesizing gold-nano-particles carrying carbohydrate moieties have been developed and the method is much more convenient than a traditional method. Expection of the glyco-gold-nanoparticle is display of multivalent carbohydrate moieties on the surface and show of effective interaction with pathogens. In addition it has capability of applying to diagnostric use such as medical test kit.
Japanese
CiNii Articles ID：120003088323 Improvements in photoconductive characteristics of organic device using silole derivative Takeshi Fukuda; Ryohei Kobayashi; Norihiko Kamata; Satoshi Aihara; Hokuto Seo; Ken Hatano; Daiyo Terunuma
Japanese Journal of Applied Physics,
Volume：49,
Number：1,
First page：01AC05-1-01AC05-4, 2010
English
DOI：https://doi.org/10.1143/JJAP.49.01AC05DOI ID：10.1143/JJAP.49.01AC05,
ISSN：0021-4922,
SCOPUS ID：77950801842 Improvements in Photoconductive Characteristics of Organic Device Using Silole Derivative Takeshi Fukuda; Ryohei Kobayashi; Norihiko Kamata; Satoshi Aihara; Hokuto Seo; Ken Hatano; Daiyo Terunuma
JAPANESE JOURNAL OF APPLIED PHYSICS,
Volume：49,
Number：1,
First page：01AC05-1-01AC05-4, 2010
English
DOI：https://doi.org/10.1143/JJAP.49.01AC05DOI ID：10.1143/JJAP.49.01AC05,
ISSN：0021-4922,
Web of Science ID：WOS:000279288900021 Synthesis and Characterization of Photo-Responsive Carbosilane Dendrimers Tetsuo Koyama; Ken Hatano; Koji Matsuoka; Yasuaki Esumi; Daiyo Terunuma
MOLECULES,
Volume：14,
Number：6,
First page：2226,
Last page：2234, Jun. 2009
English
DOI：https://doi.org/10.3390/molecules14062226DOI ID：10.3390/molecules14062226,
ISSN：1420-3049,
Web of Science ID：WOS:000267339500024 Color-selective organic photoconductive device fabricated by wet process
福田 武司; 小林 諒平; 幡野 健; 鎌田 憲彦; 照沼 大陽
Number：2, First page：56, Last page：60, 2009
Organic image sensor have been attracting considerable attention for sensing applications owing toseveral special characteristics compared to semiconductor materials, such as high absorption coefficient, flexibility, stacked structure, and low fabrication cost. By now, our research group reported a color selective organic photoconductive device via a wet process. In this report, we investigated optical characteristics of a blue-sensitive organic photoconductive device by doping several silole derivatives to improve a device performance. We used poly(dioctylfluorenyl-co-benzo-thiadiazole) [F8BT] as a photoconductive and bluesensitive polymer because of its high carrier mobility and absorption coefficient. Most of silole derivativesshowed only the absorption bands at blue or violet wavelength regions. Therefore, silole derivative is found to be suitable material for a blue-sensitive organic photoconductive device. A maximum external quantum efficiency of 8.9% was obtained by doping 1,1-dimethyl-2,5-bis(N,N-dimethylaminophenyl)-3,4-diphenylsilole in F8BT. This value was two orders higher than that of the reference device with F8BT only.
Japanese
ISSN：1883-8278, CiNii Articles ID：120002354120, CiNii Books ID：AA12486867
Systematic syntheses of influenza neuraminidase inhibitors: A series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties. Jun-Ichi Sakamoto; Tetsuo Koyama; Daisei Miyamoto; Sangchai Yingsakmongkon; Kazuya I.P.J. Hidari; Wipawee Jampangern; Takashi Suzuki; Yasuo Suzuki; Yasuaki Esumi; Takemichi Nakamura; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
Bioorg. Med. Chem.,
Volume：17,
First page：5451,
Last page：5464, 2009
DOI：https://doi.org/10.1016/j.bmc.2009.06.036DOI ID：10.1016/j.bmc.2009.06.036 Synthetic construction of a Le(x) determinant via gabriel amine synthesis and the glycopolymer involving highly clustered Le(x) residues K. Matsuoka; T. Kohzu; T. Hakumura; T. Koyama; K. Hatano; D. Terunuma
Tetrahedron Letters,
Volume：50,
Number：21,
First page：2593,
Last page：2596, 2009
DOI：https://doi.org/10.1016/j.tetlet.2009.03.099DOI ID：10.1016/j.tetlet.2009.03.099,
ISSN：0040-4039,
CiNii Articles ID：80020274265 Use of a recycle-type SEC method as a powerful tool for purification of thiosialoside derivatives Jun-Ichi Sakamoto; Chiharu Takita; Tetsuo Koyama; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
CARBOHYDRATE RESEARCH,
Volume：343,
Number：16,
First page：2735,
Last page：2739, Nov. 2008
English
DOI：https://doi.org/10.1016/j.carres.2008.05.014DOI ID：10.1016/j.carres.2008.05.014,
ISSN：0008-6215,
CiNii Articles ID：80019881611,
Web of Science ID：WOS:000260735900003 Synthesis and lectin-binding activity of luminescent silica particles peripherally functionalized with lactose Ken Hatano; Tetsuya Yamazaki; Koji Yoshino; Naoto Ohyama; Tetsuo Koyama; Koji Matsuoka; Daiyo Terunuma
TETRAHEDRON LETTERS,
Volume：49,
Number：39,
First page：5593,
Last page：5596, Sep. 2008
English
DOI：https://doi.org/10.1016/j.tetlet.2008.07.034DOI ID：10.1016/j.tetlet.2008.07.034,
ISSN：0040-4039,
CiNii Articles ID：80019747433,
Web of Science ID：WOS:000259309700008 Sialyl alpha(2 -> 3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers Hiroyuki Oka; Tomotsune Onaga; Tetsuo Koyama; Chao-Tan Guo; Yasuo Suzuki; Yasuaki Esumi; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
Volume：18,
Number：15,
First page：4405,
Last page：4408, Aug. 2008
English
DOI：https://doi.org/10.1016/j.bmcl.2008.06.101DOI ID：10.1016/j.bmcl.2008.06.101,
ISSN：0960-894X,
PubMed ID：18639456,
Web of Science ID：WOS:000257986400034 Lectin detection based on photoluminescent silole-core carbosilane dendrimer peripherally functionalized with carbohydrate佐伯 整; 幡野 健; 横田 洋大; 相澤 宏明; 小山 哲夫; 松岡 浩司; 照沼 大陽
Volume：42,
First page：14,
Last page：18, 2008
A glycocluster periphery functionalized with lactose derivative possessing a silole moiety as a luminophore was synthesized. The photoluminescence spectrum of the glycocluster showed extremely strong emission at 475 nm and the absolute quantum yield was estimated to be 92% in water. The emission intensity was decreased by increasing the amount of peanut agglutinin (PNA), lactose-binding lectin, eventually to be nearly one-twentieth of the intensity in the case of absence of PNA. The fluorescence quenching of the glycocluster on mixing with PNA can be easily distinguished with the naked-eye observation under UV irradiation. Whereas no distinct change in the fluorescence properties of the glycoclyster was observed when wheat germ agglutinin (WGA) was employed.
Japanese
CiNii Articles ID：120005373728 標的認識能を有する有機ケイ素-糖鎖ハイブリッド材料
照沼大陽; 松岡浩司; 幡野健
未来材料, Volume：8, First page：45, Last page：50, 2008
糖鎖と有機ケイ素化合物の複合による新規機能材料
幡野健; 松岡浩司; 照沼大陽
化学工業, Volume：59, Number：2, First page：95, Last page：100, 2008
Thiosialoside Clusters Using Carbosilane Dendrimer Core Scaffolds as a New Class of Influenza Neuraminidase Inhibitors J.-I. Sakamoto; T. Koyama; D. Miyamoto; S. Yingsakmongkon; K.I.P.J. Hidari; W. Jampangern; T. Suzuki; Y. Suzuki; Y. Esumi; K. Hatano; D. Terunuma; K. Matsuoka
Bioorg. Med. Chem. Lett.,
Volume：17,
Number：3,
First page：717,
Last page：721, 2007
DOI：https://doi.org/10.1016/j.bmcl.2006.10.085DOI ID：10.1016/j.bmcl.2006.10.085,
ISSN：0960-894X,
PubMed ID：17095224 Practical Synthesis of Fully Protected Globotriaose and Its Glycopolymers K. Matsuoka; Y. Goshu; Y. Takezawa; T. Mori; J.-I. Sakamoto; A. Yamada; T. Onaga; T. Koyama; K. Hatano; P. W. Snyder; E. J. Toone; D. Terunuma
Carbohydr. Polym.,
Volume：69,
Number：2,
First page：326,
Last page：335, 2007
DOI：https://doi.org/10.1016/j.carbpol.2006.10.011DOI ID：10.1016/j.carbpol.2006.10.011,
ISSN：0144-8617,
CiNii Articles ID：80018527330 Novel Linear Polymers Bearing Thiosialosides as Pendant-type Epitopes for Influenza Neuraminidase Inhibitors K. Matsuoka; C. Takita; T. Koyama; D. Miyamoto; S. Yingsakmongkon; K. I.P.J. Hidari; W. Jampangern; T. Suzuki; Y. Suzuki; K. Hatano; D. Terunuma
Bioorg. Med. Chem. Lett.,
Volume：17,
Number：14,
First page：3826,
Last page：3830, 2007
DOI：https://doi.org/10.1016/j.bmcl.2007.05.016DOI ID：10.1016/j.bmcl.2007.05.016,
ISSN：0960-894X,
PubMed ID：17524642 Lactotriaose-containing carbosilane dendrimers: syntheses and lectin-binding activities A. Yamada; K. Hatano; T. Koyama; K. Matsuoka; N. Takahashi; K.I.P.J. Hidari; Y. Suzuki; D. Terunuma
Bioorg. Med. Chem.,
Volume：15,
Number：4,
First page：1606,
Last page：1614, 2007
DOI：https://doi.org/10.1016/j.bmc.2006.12.030DOI ID：10.1016/j.bmc.2006.12.030 患部の蛍光標識を目指した糖鎖ーケイ素ハイブリッド型材料の開発に関する基礎研究
幡野 健
Number：5(18年度), First page：543, Last page：544, 2007
患部の蛍光標識を目指した糖鎖ーケイ素ハイブリッド型材料の開発に関する基礎研究
幡野 健
総合研究機構研究プロジェクト研究成果報告書, Number：5(18年度), First page：543, Last page：544, 2007
Thiosialoside Clusters as Inhibitors for Influenza Virus Neuraminidases
J.-I. Sakamoto; C. Takita; T. Koyama; K. Hatano; D. Terunuma; Y. Esumi; K. I.-P; J. Hidari; S. Yingsakmongkon; D. Miyamoto; W. Usawattanakul; T. Suzuki; Y. Suzuki; K. Matsuoka
22nd International Symposium on the Organic Chemistry of Sulfur, First page：173, 2006
Synthetic Construction of Novel Sugar―Amino Acid Hybrid Materials Using Typical Radical Polymerization Protocol
K. Matsuoka; Y. Goshu; T. Koyama; K. Hatano; D. Terunuma
XXIIIrd International Carbohydrate Symposium, First page：275, 2006
Synthesis of a Series of Carbosilane Dendrimers Having Thioglycoside-type Sialic Acid Moieties
J.-I. Sakamoto; T. Koyama; Y. Esumi; H. Koshino; K. I.-P; J. Hidari; T. Suzuki; Y. Suzuki; K. Hatano; D. Terunuma; K. Matsuoka
XXIIIrd International Carbohydrate Symposium, First page：279, 2006
Syntheses of a Series of Lacto-N-neotetraose Clusters using a Carbosilane Dendrimer Scaffold A. Yamada; K. Hatano; T. Koyama; K. Matsuoka; Y. Esumi; Daiyo Terunuma
Carbohydr. Res.,
Volume：341,
Number：4,
First page：467,
Last page：473, 2006
DOI：https://doi.org/10.1016/j.carres.2005.11.037DOI ID：10.1016/j.carres.2005.11.037,
ISSN：0008-6215,
CiNii Articles ID：80019328422,
PubMed ID：16386236 Carbosilane Dendrimers Bearing Globotriaoses: Syntheses of Globotrioasyl Derivative and Introduction into Carbosilane Dendrimers K. Matsuoka; M. Terabatake; A. Umino; Y. Esumi; K. Hatano; D. Terunuma; H. Kuzuhara
Biomacromolecules,
Volume：7,
Number：8,
First page：2274,
Last page：2283, 2006
DOI：https://doi.org/10.1021/bm060368+DOI ID：10.1021/bm060368+,
ISSN：1525-7797,
CiNii Articles ID：80018973734,
PubMed ID：16903671 Carbosilane Dendrimers Bearing Globotriaoses: Construction of A Series of Carbosilane Dendrimers Bearing Globotriaoses K. Matsuoka; M. Terabatake; Y. Esumi; K. Hatano; D. Terunuma; H. Kuzuhara
Biomacromolecules,
Volume：7,
Number：8,
First page：2284,
Last page：2290, 2006
DOI：https://doi.org/10.1021/bm0603692DOI ID：10.1021/bm0603692,
ISSN：1525-7797,
CiNii Articles ID：80018973735,
PubMed ID：16903672 Identification of the Optimal Structure Required for a Shiga Toxin Neutralizer with Oriented Carbohydrates to Function in the Circulation K. Nishikawa; K. Matsuoka; M. Watanabe; K. Igai; K. Hino; K. Hatano; A. Yamada; N. Abe; D. Terunuma; H. Kuzuhara; Y. Natori
J. Infect. Dis.,
Volume：191,
Number：12,
First page：2097,
Last page：2105, 2005
DOI：https://doi.org/10.1086/430388DOI ID：10.1086/430388 グロボ三糖担持カルボシランデンドリマーの合成 -カルボシランデンドリマー構造がO157:H7が産生するベロ毒素の阻害活性に及ぼす効果- (Review) 照沼大陽; 松岡浩司; 幡野健
有機合成化学協会誌,
Volume：63,
Number：7,
First page：722,
Last page：727, 2005
DOI：https://doi.org/10.5059/yukigoseikyokaishi.63.722DOI ID：10.5059/yukigoseikyokaishi.63.722,
ISSN：0037-9980,
CiNii Articles ID：10016587901 Synthesis of Carbosilane Dendrimers Having Peripheral Mannose and Mannobiose T. Mori; K. Hatano; K. Matsuoka; Y. Esumi; E. J. Toone; D. Terunuma
Tetrahedron,
Volume：61,
Number：11,
First page：2751,
Last page：2760, 2005
DOI：https://doi.org/10.1016/j.tet.2005.01.090DOI ID：10.1016/j.tet.2005.01.090,
ISSN：0040-4020,
CiNii Articles ID：80017259179 Syntheses and Biological Assay of a Series of Lacto-N-neotetraose Cluster using Carbosilane Dendrimer Scaffolds
Akihiro, Yamada; Ken Hatano; Koji Matsuoka; Yasuaki Esumi; Chie Aoki; Kazuya Hidari; Yasuo Suzuki; Daiyo Terunuma
The 14th International Symposium on Organosilicon Chemistry, First page：134, 2005
Advantages of Carbosilane Dendrimer as a Carbohydrate Scaffold --Application to Artificial Receptor of E. Coli, Influenza and Dengue Virus--
Ken Hatano; Akihiro Yamada; Tetsuo Koyama; Koji Matsuoka; Daiyo Terunuma; Yasuaki Esumi; Kiyotaka Nishikawa; Yasuhiro Natori; Kazuya Hidari; Yasuo Suzuki
The 14th International Symposium on Organosilicon Chemistry, First page：78, 2005
カルボシランデンドリマー・糖鎖複合材料の開発 : 大腸菌O157の産生するベロ毒素中和剤への応用<論文>
幡野 健; 松岡 浩司; 照沼 大陽
Volume：1, Number：38, First page：40, Last page：44, 2005
カルボシランデンドリマー・糖鎖複合材料の開発 : 大腸菌O157の産生するベロ毒素中和剤への応用<論文>幡野 健; 松岡 浩司; 照沼 大陽
埼玉大学紀要, 工学部, 第1部論文集,
Volume：1,
Number：38,
First page：40,
Last page：44, 2005
Carbosilane dendrimer periphery bearing globotiaose were synthesized by SN2 reaction of thiolate anion at aglycon of globotriaose and brominated carbosilane dendrimer. Binding assay of tree shapes of carbosilane dendrimers [Fan(0)3, Dumbbell(1)6 and Ball(1)12] were carried out. Vero toxin classified into two closely related subgroups, Stx1 and Stx2. Dumbbell(1)6 and Ball(1)12 markedly inhibited the cytotoxic activity of both Stx1 (0.22 and 0.16 μg/ml respectively) and Stx2 (2.3 and 1.3 μg/ml, respectively) toward Vero cells; whereas the IC50 of Fan(0)3 was more than 100 μg/ml. The result of the binding assay of these toxins suggested that Dumbbell(1)6 and Ball(1)12 bind to both Stx1 and Stx2 with high affinities. Furthermore, inhibitory effects of these dendrimers on the lethality of intravenously administered Stx2 in mice were investigated. Dumbbell(1)6 completely suppressed the lethal effect of Stx2 when administered along with the toxin. The dendrimer treated mice survived more than 2 months without any pathological symptoms.
Japanese
ISSN：1880-4446,
CiNii Articles ID：120001370805 Synthesis of a useful lauryl thioglycoside of sialic acid and its application K Matsuoka; T Onaga; T Mori; JI Sakamoto; T Koyama; N Sakairi; K Hatano; D Terunuma
TETRAHEDRON LETTERS,
Volume：45,
Number：51,
First page：9383,
Last page：9386, Dec. 2004
English
DOI：https://doi.org/10.1016/j.tetlet.2004.10.105DOI ID：10.1016/j.tetlet.2004.10.105,
ISSN：0040-4039,
CiNii Articles ID：80017025809,
Web of Science ID：WOS:000225648700017 Synthesis and biological evaluation of glycopolymer as Shiga toxin neutralizer
K Matsuoka; A Miyagawa; K Nishikawa; M Watanabe; Y Natori; E Kita; T Koyama; K Hatano; D Terunuma
GLYCOBIOLOGY, Volume：14, Number：11, First page：1194, Last page：1194, Nov. 2004
English, Summary international conference
ISSN：0959-6658, Web of Science ID：WOS:000224206400508
Synthesis and Property of Carbosilane Dendrimers Functionalizing Peripheral Mannose Moieties
T. Mori; K. Hatano; K. Matsuoka; Y. Esumi; E. J. Toone; D. Terunuma
Glycobiology, Volume：14, First page：1093, 2004
Glyco-silicon functional materials. Part 6. Synthesis of a useful anomeric thioacetate of an N-acetyllactosamine derivative and its application K Matsuoka; T Ohtawa; H Hinou; T Koyama; Y Esumi; SI Nishimura; K Hatano; D Terunuma
TETRAHEDRON LETTERS,
Volume：44,
Number：18,
First page：3617,
Last page：3620, Apr. 2003
English
DOI：https://doi.org/10.1016/S0040-4039(03)00697-XDOI ID：10.1016/S0040-4039(03)00697-X,
ISSN：0040-4039,
CiNii Articles ID：120001370836,
Web of Science ID：WOS:000182496400006 新規カルボシランデンドリマーの合成とその構造が液晶性に与える効果 土田隆樹; 島崎智恵美; 幡野健; 松岡浩司; 青木良夫; 野平博之; 江角保明; 照沼大陽
高分子論文集,
Volume：60,
Number：10,
First page：561,
Last page：568, 2003
DOI：https://doi.org/10.1295/koron.60.561DOI ID：10.1295/koron.60.561,
ISSN：0386-2186,
CiNii Articles ID：10012446351 Synthesis of Kinetically Stabilized Silaneselone and Silanetellone
TOKITOH Norihiro; SADAHIRO Tomonori; HATANO Ken; SASAKI Takayo; TAKEDA Nobuhiro; OKAZAKI Renji
Volume：2002, Number：1, First page：34, Last page：35, 05 Jan. 2002
English
ISSN：0366-7022, CiNii Articles ID：10009618528, CiNii Books ID：AA00603318
The first stable heteracyclopropabenzene: Synthesis and crystal structure of a silacyclopropabenzene K Hatano; N Tokitoh; N Takagi; S Nagase
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
Volume：122,
Number：19,
First page：4829,
Last page：4830, May 2000
English
DOI：https://doi.org/10.1021/ja000501kDOI ID：10.1021/ja000501k,
ISSN：0002-7863,
CiNii Articles ID：80011785034,
Web of Science ID：WOS:000087118100043 The first stable heteracyclopropabenzene: Synthesis and crystal structure of a silacyclopropabenzene K Hatano; N Tokitoh; N Takagi; S Nagase
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
Volume：122,
Number：19,
First page：4829,
Last page：4830, May 2000
English
DOI：https://doi.org/10.1021/ja000501kDOI ID：10.1021/ja000501k,
ISSN：0002-7863,
CiNii Articles ID：80011785034,
Web of Science ID：WOS:000087118100043 Steric stabilization of nucleophilic carbenes
MK Denk; A Thadani; K Hatano; AJ Lough
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Volume：36, Number：23, First page：2607, Last page：2609, Dec. 1997
English
ISSN：1433-7851, Web of Science ID：WOS:000071234500008
Steric stabilization of nucleophilic carbenes
MK Denk; A Thadani; K Hatano; AJ Lough
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Volume：36, Number：23, First page：2607, Last page：2609, Dec. 1997
English
ISSN：1433-7851, Web of Science ID：WOS:000071234500008
SYNTHESIS AND REDUCTION OF THE 9,10-DISILAANTHRACENE DIMER W ANDO; K HATANO; R URISAKA
ORGANOMETALLICS,
Volume：14,
Number：8,
First page：3625,
Last page：3627, Aug. 1995
English, Introduction scientific journal
DOI：https://doi.org/10.1021/om00008a007DOI ID：10.1021/om00008a007,
ISSN：0276-7333,
CiNii Articles ID：80008489557,
Web of Science ID：WOS:A1995RQ47100007
シロールをコアとする糖鎖担持カルボシランデンドリマーの合成とその光学特性の調査
2009
シロキサン類を集積場に用いた糖鎖クラスター化合物の合成
2009
シロールをコアとした糖鎖担持カルボシランデンドリマーによるレクチン検出評価
2009
Poster presentation
シロールをコアとする糖鎖担持カルボシランデンドリマーの合成とその光学特性の調査
日本化学会第89回春季年会講演予稿集, 2009
シロキサン類を集積場に用いた糖鎖クラスター化合物の合成
日本化学会第89回春季年会講演予稿集, 2009
シロールをコアとした糖鎖担持カルボシランデンドリマーによるレクチン検出評価
日本化学会第89回春季年会講演予稿集, 2009
Poster presentation
シロール含有糖鎖担持カルボシランデンドリマーに関する研究
2008
Poster presentation
機能性糖鎖を表面に修飾したシリカ微粒子の調製と評価
2008
Poster presentation
機能性糖鎖で修飾した発光物質含有有機微粒子の合成
2008
Poster presentation
糖鎖修飾型デンドリマーの分子認識蛍光試剤への応用:水中及び有機溶剤中における蛍光強度の変化と凝集状態の観測
2008
Poster presentation
Synthesis and Lectin-binding Activities of Carbohydrate-modified Polysiloxanes
2008
Poster presentation
Syntheses and Photoluminescence of Silole Core Carbosilane Dendrimers Peripheral Functionalize with Carbohydrates
2008
Poster presentation
Highly luminescent glycocluster in organic solvent: silole-core carbosilane dendrimer having peripheral globotriaose
2008
Poster presentation
機能性糖鎖を表面に修飾したシリカ微粒子の調製と評価
2008
Poster presentation
機能性糖鎖で修飾した発光物質含有有機微粒子の一段階合成
2008
Poster presentation
シロール含有糖鎖担持カルボシランデンドリマーに関する研究
第3回バイオ関連化学合同シンポジウム予稿集, 2008
Poster presentation
機能性糖鎖を表面に修飾したシリカ微粒子の調製と評価
第3回バイオ関連化学合同シンポジウム予稿集, 2008
Poster presentation
機能性糖鎖で修飾した発光物質含有有機微粒子の合成
第3回バイオ関連化学合同シンポジウム予稿集, 2008
Poster presentation
糖鎖修飾型デンドリマーの分子認識蛍光試剤への応用:水中及び有機溶剤中における蛍光強度の変化と凝集状態の観測
第3回バイオ関連化学合同シンポジウム予稿集, 2008
Poster presentation
Synthesis and Lectin-binding Activities of Carbohydrate-modified Polysiloxanes
Post ISOS XV Symposium Abstracts, 2008
Poster presentation
Syntheses and Photoluminescence of Silole Core Carbosilane Dendrimers Peripheral Functionalize with Carbohydrates
Post ISOS XV Symposium Abstracts, 2008
Poster presentation
Highly luminescent glycocluster in organic solvent: silole-core carbosilane dendrimer having peripheral globotriaose
Post ISOS XV Symposium Abstracts, 2008
Poster presentation
機能性糖鎖を表面に修飾したシリカ微粒子の調製と評価
57回高分子学会年次大会予稿集, 2008
Poster presentation
機能性糖鎖で修飾した発光物質含有有機微粒子の一段階合成
57回高分子学会年次大会予稿集, 2008
Poster presentation
Development of high-brightness luminescent beads using aggregation-induced emission materials and application to highly sensitive detection of viruses
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), 01 Apr. 2017 - 31 Mar. 2020
Hatano Ken, Saitama University
Grant amount(Total)：4550000, Direct funding：3500000, Indirect funding：1050000
n this study, we have developed beads that emit light with high brightness by incorporating aggregation-induced emission materials into polystyrene beads. As a result, we were able to develop beads that emit light with high brightness, reaching a quantum yield of 90%. Further, using the beads as a core, surface functionalization, PEG chain modification, and sensitization with an anti-influenza antibody were performed to obtain a labeled antibody for an immunochromatography kit. Using this labeled antibody, an immunochromatography kit for influenza was prototyped. Comparing the detection sensitivity with a commercially available influenza immunochromatography kit that uses an antibody labeled with colloidal gold, it was found that the detection kit using the developed beads can detect influenza with 100 times higher sensitivity.
Grant number：17K01958
Development of one step synthesis of glycosyl acceptor substituted by overcrowded silyl group and regioselective glycosidation at 3-OH
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), 01 Apr. 2013 - 31 Mar. 2016
HATANO Ken, Saitama University
Grant amount(Total)：5200000, Direct funding：4000000, Indirect funding：1200000
Silylation of hydroxyl groups on monosaccharides and lactose were obtained in good yield by one step reaction. In the case of lactose, the silylation occurred on 6, 2' and 6' positions of hydroxyl groups and the trisilylated lactose was able to isolate by recrystallization. Regioselective glycosydation at 3-OH (however 3'-OH in the case of lactose) of the silylated saccharides with a glucose derivative as a glycosyl donor were observed.
Grant number：25410170
Development of Carbohydrate-Silicon Functional Material to Detect Avian Influenza Virus
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), 2009 - 2011
HATANO Ken, Saitama University
Grant amount(Total)：4940000, Direct funding：3800000, Indirect funding：1140000
We succeeded a synthesis of a novel carbosilane dendrimer functionalized aggregation-induced emission (AIE) active 2, 3, 4, 5 tetraphenyl1silacyclo-pentadiene at the core and periphery functionalized avian influenza virus binding 3'-sialyllactose as an avian inluruenza detection agent. Detection test of the virus using the dendrimer prepared here is currently in progress.
Grant number：21550152
ケイ素橋頭位化合物の構造特性を活用した新規導電性高分子の開発に関する基礎研究
2004 - 2006
Grant amount(Total)：3600000, Direct funding：3600000
Grant number：16750026
Development of electroluminescence device containing water soluble polysilane and organic dyes in sol-gel glass
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), 2002 - 2004
TERUNUMA Daiyo; KAMATA Norihiko; HATANO Ken; HONDA Zentaro, Saitama University
Grant amount(Total)：6200000, Direct funding：6200000
It is known that polysilanes display unique characteristics such as UV absorption, photo-, and electroluminescence due to σ-conjugation of the Si-Si main chain. We have been studied the preparation of new water-soluble polysilane, the energy transfer and radiative properties of polysilanes, and energy-matched counterparts. And, it was found that photo-oxidation during irradiation an ultraviolet light was suppressed by using water-soluble polysilanes and embedding them inside sol-gel glass matrices. However, there are problems for the preparation of watersoluble polysilanes, because Wurtz type reaction usually gives only a low yield. So, it is important to improve the way for the synthesis of water-soluble polysilanes.
We have interested in the use of commercially available dodecaphenylcyclopentasilane(DPCPS). DPCPS was treated with Li in tetrahydrofuran to give ring opening intermediate ; α, ω-dilithiododecaphenylpetasilane. Reaction of the intermediate with an equimolecular amount of dichlorodimethylsilane afforded cyclic polysilanes, resulted from intramolecular cyclization reaction, and a small amount of low molecular-weight polymer. On the other hand, the treatment of the intermediate with an equimolecular amount of 1,2-dichlorotetramethyldisilane gave higher molecular weight polysilane co-polymer as a result of predominant intermolecular reaction.
The obtained co-polymer was successfully converted into water-soluble polysilane derivative by successive Friedel-Crafts chloromethylation and quaternary ammonium reaction.
The intermolecular energy transfer from conductive poly(m-hexoxyphenyl)phenylsilane was utilized for electroluminescence(EL) of perylene (blue), coumarin 6 (green), 4-(dicyanometliylene)-2-methyl-6-(p-dimethylammostyryl)-4H-pyran and Zinc tetra-phenylporphyrin (red). A white EL was also observed by mixing the four dyes. Photo-oxidation during irradiating a ultraviolet light was suppressed by synthesizing water-soluble polysilanes and embedding it inside sol-gel glass matrices. These results imply that polysilanes have a possibility to open new fields of optical application.
Grant number：14350158
-
Competitive research funding
-
Competitive research funding
