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MATSUOKA Keisuke
Natural science courseAssociate Professor
Graduate School of Education

Researcher information

■ Field Of Study
  • Natural sciences, Bio-, chemical, and soft-matter physics
■ Educational Background
  • Apr. 2000 - Mar. 2003, Kyushu University
  • Apr. 1993 - Mar. 1995, Kyushu University
  • Apr. 1989 - Mar. 1993, Kyushu University, School of Sciences, Department of Chemistry
■ Award
  • 2017, 20th J. Oleo Sci. Editor's Award
    Tomokazu Yoshimura;Mari. Okada;Keisuke Matsuoka
  • 2010, オレオマテリアル賞

Performance information

■ Paper
  • Distinct Solubilization Mechanisms of Medroxyprogesterone in Gemini Surfactant Micelles: A Comparative Study with Progesterone               
    Hiromichi Nakahara; Kazutaka Koga; Keisuke Matsuoka
    Molecules, Volume:29, Number:20, Oct. 2024, [Reviewed]
    Scientific journal
    DOI:https://doi.org/10.3390/molecules29204945
    Scopus:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85207674635&origin=inward
    Scopus Citedby:https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85207674635&origin=inward
    DOI ID:10.3390/molecules29204945, eISSN:1420-3049, PubMed ID:39459313, SCOPUS ID:85207674635
  • Solubilization of polycyclic aromatic compounds into supralong-chain surfactants with double quaternary ammonium micelles               
    Keisuke Matsuoka; Rina Sekiguchi; Tomokazu Yoshimura; Hiromichi Nakahara; Kazutaka Koga
    Journal of Molecular Liquids, Volume:405, Jul. 2024, [Reviewed]
    Scientific journal
    DOI:https://doi.org/10.1016/j.molliq.2024.125109
    Scopus:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85194340088&origin=inward
    Scopus Citedby:https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85194340088&origin=inward
    DOI ID:10.1016/j.molliq.2024.125109, ISSN:0167-7322, SCOPUS ID:85194340088
  • Micelle formation of sodium taurolithocholate               
    Keisuke Matsuoka; Rina Sekiguchi; Tomokazu Yoshimura
    Chemistry and Physics of Lipids, Volume:259, First page:105378, Last page:105378, Mar. 2024, [Reviewed]
    Elsevier BV, Scientific journal
    DOI:https://doi.org/10.1016/j.chemphyslip.2024.105378
    DOI ID:10.1016/j.chemphyslip.2024.105378, ISSN:0009-3084
  • Solubilization of progesterone into Gemini surfactant solutions: 2D ROESY spectroscopy               
    Hiromichi Nakahara; Kazutaka Koga; Keisuke Matsuoka
    Journal of Molecular Liquids, Volume:395, Feb. 2024, [Reviewed]
    Scientific journal
    DOI:https://doi.org/10.1016/j.molliq.2023.123841
    Scopus:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85180969731&origin=inward
    Scopus Citedby:https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85180969731&origin=inward
    DOI ID:10.1016/j.molliq.2023.123841, ISSN:0167-7322, SCOPUS ID:85180969731
  • Micelle Formation of Dodecanoic Acid with Alkali Metal Counterions
    Keisuke Matsuoka; Aiko Sato; Yukino Ogawa; Kana Okazaki; Shiho Yada; Tomokazu Yoshimura
    Journal of Oleo Science, Volume:72, Number:9, First page:831, Last page:837, Jun. 2023, [Reviewed]
    Japan Oil Chemists' Society, Scientific journal
    DOI:https://doi.org/10.5650/jos.ess23086
    DOI ID:10.5650/jos.ess23086, ISSN:1345-8957, eISSN:1347-3352
  • Preferential Removal of Alkali Metal Using Dodecanoic Acid and Sodium Dodecyl Sulfate in Foam Separation System.               
    Keisuke Matsuoka; Daichi Asamoto
    Journal of oleo science, Volume:72, Number:5, First page:543, Last page:548, Feb. 2023, [Reviewed], [Domestic magazine]
    The selectivity of adsorption between alkali metal ions (Li+, Na+, K+, Rb+, and Cs+) based on the ionic functional groups of the surfactants was studied using two types of surfactants, dodecanoic acid (DA) and sodium dodecyl sulfate (SDS), in the foam separation system. The results showed that Li+ was preferably removed by foam separation using DA. The removal rates of other alkali metal ions were relatively low, and there were no significant differences among other alkali metal ions (Na+, K+, Rb+, and Cs+). However, Cs+ exhibited the highest removal rate among the mixed alkali metals by foam separation using SDS. From these results, the selectivity of the alkali metal in foam separation was dependent on the type of surfactant.
    English, Scientific journal
    DOI:https://doi.org/10.5650/jos.ess22422
    DOI ID:10.5650/jos.ess22422, PubMed ID:37121679
  • Removal of ionic dyes with different charges by foam separation               
    Keisuke Matsuoka; Yui Sato; Sumire Takashima; Yusuke Goto
    Journal of Molecular Liquids, Volume:355, First page:118994, Last page:118994, Jun. 2022, [Reviewed]
    Elsevier BV, Scientific journal
    DOI:https://doi.org/10.1016/j.molliq.2022.118994
    DOI ID:10.1016/j.molliq.2022.118994, ISSN:0167-7322
  • Vesicle formation of disodium lauryl sulfosuccinate               
    Keisuke Matsuoka; Nanami Noshiro; Hikaru Kuroki; Kohta Tsuyuzaki; Goro Hashimoto
    Journal of Molecular Liquids, Volume:348, First page:118422, Last page:118422, Feb. 2022, [Reviewed]
    Elsevier BV, Scientific journal
    DOI:https://doi.org/10.1016/j.molliq.2021.118422
    DOI ID:10.1016/j.molliq.2021.118422, ISSN:0167-7322
  • Solubilization of fullerene in polyoxyethylene tetradecyl ether type nonionic surfactants               
    Hikaru Kuroki; Erika Aida; Takuya Komine; Keisuke Matsuoka
    Journal of Molecular Liquids, Volume:335, Aug. 2021, [Reviewed]
    Scientific journal
    DOI:https://doi.org/10.1016/j.molliq.2021.116236
    Scopus:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85105693362&origin=inward
    Scopus Citedby:https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85105693362&origin=inward
    DOI ID:10.1016/j.molliq.2021.116236, ISSN:0167-7322, SCOPUS ID:85105693362
  • Removal of period 4 transition metals by foam separation               
    Keisuke Matsuoka; Nana Yamaguchi
    JOURNAL OF MOLECULAR LIQUIDS, Volume:325, Mar. 2021, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.molliq.2020.115185
    DOI ID:10.1016/j.molliq.2020.115185, ISSN:0167-7322, eISSN:1873-3166, Web of Science ID:WOS:000636695200104
  • Micelle Formation of Monoammonium Glycyrrhizinate               
    Keisuke Matsuoka; Mamoru Arima; Yusuke Goto; Shiho Yada; Tomokazu Yoshimura
    JOURNAL OF OLEO SCIENCE, Volume:70, Number:7, First page:911, Last page:918, 2021, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.5650/jos.ess21046
    DOI ID:10.5650/jos.ess21046, ISSN:1345-8957, eISSN:1347-3352, Web of Science ID:WOS:000670011000004
  • Foam Separation of Dyes Using Anionic, Cationic, and Amphoteric Surfactants.               
    Yusuke Goto; Yuya Nema; Keisuke Matsuoka
    Journal of oleo science, Volume:69, Number:6, First page:549, Last page:555, 2020, [Reviewed], [Domestic magazine]
    Foam separation can selectively remove a target substance from a solution via adsorption of the substance with the surfactant at the surface of the bubble. A cationic dye, methylene blue, and an anionic dye, Fast Green FCF, were prepared as substances to be removed via foam separation. Anionic (sodium dodecyl sulfate, SDS), cationic (dodecyltrimethylammonium chloride, DTAC), and amphoteric (3-(dodecyldimethylammonio)propane-1-sulfonate, SB-12) surfactants were used in the foam separation process. The effectiveness of the surfactants for removing the cationic methylene blue increased as follows: DTAC < SB-12 < SDS. On the other hand, the effectiveness of the surfactants for removing the anionic Fast Green FCF was in the opposite order. The dyes were effectively adsorbed by the foams via electrostatic interactions between the oppositely charged surfactant and the dye molecules. Since amphoteric surfactants have both anionic and cationic charges in a molecule, they could effectively remove both dyes in the foam separation process. Therefore, it was found that the amphoteric surfactant was highly versatile. Analysis of the kinetics of the removal rate showed that the aqueous solutions of monomers could remove the dyes more effectively than micellar solutions in foam separation.
    English, Scientific journal
    DOI:https://doi.org/10.5650/jos.ess20004
    DOI ID:10.5650/jos.ess20004, PubMed ID:32522916
  • Removal of Zwitterionic Rhodamine B Using Foam Separation.               
    Yusuke Goto; Yuya Nema; Keisuke Matsuoka
    Journal of oleo science, Volume:69, Number:6, First page:563, Last page:567, 2020, [Reviewed], [Domestic magazine]
    Foam separation promotes the removal of dissolved materials from solutions by adsorbing the molecules onto a surfactant. The zwitterion of rhodamine B was removed by using both anionic (sodium dodecyl sulfate: SDS) and cationic (dodecyltrimethylammonium chloride: DTAC) surfactants through foam separation. However, rhodamine B could not be removed from a strongly acidic DTAC solution (pH 2), because the molecular form changes from the zwitterion to cation. Moreover, the cationic dye of rhodamine 6G could not be removed from the DTAC solution. Therefore, these results demonstrate that the electrostatic interaction between a surfactant and target ion is an important factor in foam separation.
    English, Scientific journal
    DOI:https://doi.org/10.5650/jos.ess20005
    DOI ID:10.5650/jos.ess20005, PubMed ID:32522917
  • Application of foam separation method for removal of alkaline earth metal ions from solution
    Keisuke Matsuoka; Satomi Hasegawa; Taiyo Yuma; Yusuke Goto
    Journal of Molecular Liquids, Volume:294, Nov. 2019, [Reviewed]
    DOI:https://doi.org/10.1016/j.molliq.2019.111663
    DOI ID:10.1016/j.molliq.2019.111663, ISSN:0167-7322, SCOPUS ID:85071718760
  • Solubilization ability of star-shaped trimeric quaternary ammonium bromide surfactant
    Keisuke Matsuoka; Naohiro Takahashi; S. Yada; Tomokazu Yoshimura
    Journal of Molecular Liquids, Volume:291, Oct. 2019, [Reviewed]
    DOI:https://doi.org/10.1016/j.molliq.2019.111254
    DOI ID:10.1016/j.molliq.2019.111254, ISSN:0167-7322, SCOPUS ID:85068251951
  • Superoxide Scavenging Activity of Gold, Silver, and Platinum Nanoparticles Capped with Sugar-based Nonionic Surfactants               
    Keisuke Matsuoka; Yuka Nakatani; Tomokazu Yoshimura; Tsubasa Akasaki
    Journal of oleo science, Volume:68, First page:847, Last page:854, Sep. 2019, [Reviewed]
    DOI:https://doi.org/10.5650/jos.ess19079
    DOI ID:10.5650/jos.ess19079, PubMed ID:31484901, SCOPUS ID:85071739601
  • Emulsification, solubilization, and detergency behaviors of homogeneous polyoxypropylene-polyoxyethylene alkyl ether type nonionic surfactants               
    Yada Shiho; Matsuoka Keisuke; Kanasaki Yu Nagai; Gotoh Keiko; Yoshimura Tomokazu
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, Volume:564, First page:51, Last page:58, Mar. 2019, [Reviewed]
    DOI:https://doi.org/10.1016/j.colsurfa.2018.12.030
    DOI ID:10.1016/j.colsurfa.2018.12.030, ISSN:0927-7757, Web of Science ID:WOS:000455389200006
  • Removal of alkali metal ions from aqueous solution by foam separation method               
    Keisuke Matsuoka; Hiroaki Miura; Shiho Karima; Chiharu Taketaka; Shota Ouno; Yoshikiyo Moroi
    Journal of Molecular Liquids, Volume:263, First page:89, Last page:95, Aug. 2018, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.molliq.2018.04.136
    DOI ID:10.1016/j.molliq.2018.04.136, ISSN:0167-7322, SCOPUS ID:85046779753, Web of Science ID:WOS:000436911300011
  • Solubilization ability of N,N-dimethyl-N-alkyladamantylammonium bromide               
    Keisuke Matsuoka; Rinpei Omori; Shiho Yada; Tomokazu Yoshimura; Hiroki Iwase
    Journal of Molecular Liquids, Volume:260, First page:131, Last page:137, Jun. 2018, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.molliq.2018.03.078
    DOI ID:10.1016/j.molliq.2018.03.078, ISSN:0167-7322, SCOPUS ID:85044527704, Web of Science ID:WOS:000433645500013
  • Study on Micelle Formation of Bile Salt Using Nuclear Magnetic Resonance Spectroscopy               
    Keisuke Matsuoka; Atsushi Yamamoto
    JOURNAL OF OLEO SCIENCE, Volume:66, Number:10, First page:1129, Last page:1137, Oct. 2017, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.5650/jos.ess17063
    DOI ID:10.5650/jos.ess17063, ISSN:1345-8957, eISSN:1347-3352, Web of Science ID:WOS:000412263900007
  • Role of the spacer of Gemini surfactants in solubilization into their micelles               
    Hiromichi Nakahara; Hiroaki Nishizaka; Kensuke Iwasaki; Yu Otsuji; Mika Sato; Keisuke Matsuoka; Osamu Shibata
    JOURNAL OF MOLECULAR LIQUIDS, Volume:244, First page:499, Last page:505, Oct. 2017, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.molliq.2017.09.014
    DOI ID:10.1016/j.molliq.2017.09.014, ISSN:0167-7322, eISSN:1873-3166, Web of Science ID:WOS:000413391000057
  • Aggregate Formation of Glycyrrhetic Acid 3-O-Glucuronide               
    Keisuke Matsuoka; Ryusuke Miyajima; Seigo Karasawa
    JOURNAL OF SURFACTANTS AND DETERGENTS, Volume:20, Number:5, First page:1153, Last page:1159, Sep. 2017, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1007/s11743-017-2001-5
    DOI ID:10.1007/s11743-017-2001-5, ISSN:1097-3958, eISSN:1558-9293, Web of Science ID:WOS:000407391500016
  • Single-alkyl and multi-alkyl chain-containing amphiphilic oligomers with several sugar side chains: solution properties and nanostructural analysis of aggregates by SANS               
    Tomokazu Yoshimura; Yuka Nakatani; Keisuke Matsuoka; Kazuhiro Akutsu; Hiroki Iwase
    COLLOID AND POLYMER SCIENCE, Volume:295, Number:5, First page:793, Last page:802, May 2017, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1007/s00396-017-4063-3
    DOI ID:10.1007/s00396-017-4063-3, ISSN:0303-402X, eISSN:1435-1536, Web of Science ID:WOS:000399706800007
  • Synthesis and Solution Properties of Adamantane-Containing Quaternary Ammonium Salt-type Cationic Surfactants: Hydrocarbon-based, Fluorocarbon-based and Bola-type               
    Tomokazu Yoshimura; Mari Okada; Keisuke Matsuoka
    JOURNAL OF OLEO SCIENCE, Volume:65, Number:10, First page:843, Last page:852, Oct. 2016, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.5650/jos.ess16095
    DOI ID:10.5650/jos.ess16095, ISSN:1345-8957, eISSN:1347-3352, Web of Science ID:WOS:000384705400005
  • Aggregate formation of glycyrrhizic acid               
    Keisuke Matsuoka; Ryusuke Miyajima; Yudai Ishida; Seigo Karasawa; Tomokazu Yoshimura
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, Volume:500, First page:112, Last page:117, Jul. 2016, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.colsurfa.2016.04.032
    DOI ID:10.1016/j.colsurfa.2016.04.032, ISSN:0927-7757, eISSN:1873-4359, Web of Science ID:WOS:000375860100014
  • Competitive Solubilization of Cholesterol/Cholesteryl Oleate and Seven Species of Sterol/Stanol in Model Intestinal Solution System               
    Keisuke Matsuoka; Asumi Kase; Takashi Matsuo; Yusuke Ashida
    JOURNAL OF OLEO SCIENCE, Volume:64, Number:7, First page:783, Last page:791, Jul. 2015, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.5650/jos.ess15044
    DOI ID:10.5650/jos.ess15044, ISSN:1345-8957, eISSN:1347-3352, Web of Science ID:WOS:000357348400011
  • Solubilization of naphthalene and octafluoronaphthalene in ionic hydrocarbon and fluorocarbon surfactants               
    Keisuke Matsuoka; Rika Yamashita; Miki Ichinose; Maiko Kondo; Tomokazu Yoshimura
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, Volume:456, First page:83, Last page:91, Aug. 2014, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.colsurfa.2014.04.060
    DOI ID:10.1016/j.colsurfa.2014.04.060, ISSN:0927-7757, eISSN:1873-4359, Web of Science ID:WOS:000340318000012
  • Solubilization of polycyclic aromatic hydrocarbons in C16E7 nonionic surfactant solutions               
    Emi Takeuchi; Keisuke Matsuoka; Shigeaki Ishii; Sho Ishikawa; Chikako Honda; Kazutoyo Endo
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, Volume:441, First page:133, Last page:139, Jan. 2014, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.colsurfa.2013.09.011
    DOI ID:10.1016/j.colsurfa.2013.09.011, ISSN:0927-7757, eISSN:1873-4359, Web of Science ID:WOS:000329260800018
  • Micelle formation of sodium hyodeoxycholate               
    Keisuke Matsuoka; Kaede Takagi; Chikako Honda
    Chemistry and Physics of Lipids, Volume:172-173, First page:6, Last page:13, 2013, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.chemphyslip.2013.04.003
    DOI ID:10.1016/j.chemphyslip.2013.04.003, ISSN:1873-2941, SCOPUS ID:84878148253, Web of Science ID:WOS:000322415100002
  • Aggregation properties of supralong-chain surfactants with double or triple quaternary ammonium head groups               
    Keisuke Matsuoka; Nagisa Chiba; Tomokazu Yoshimura
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, Volume:379, First page:72, Last page:77, Aug. 2012, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.jcis.2012.04.043
    DOI ID:10.1016/j.jcis.2012.04.043, ISSN:0021-9797, Web of Science ID:WOS:000305592000011
  • Supra-long chain surfactants with double or triple quaternary ammonium headgroups               
    Tomokazu Yoshimura; Nagisa Chiba; Keisuke Matsuoka
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, Volume:374, First page:157, Last page:163, May 2012, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.jcis.2012.01.033
    DOI ID:10.1016/j.jcis.2012.01.033, ISSN:0021-9797, Web of Science ID:WOS:000302446900022
  • Competitive solubilization of cholesterol and beta-sitosterol with changing biliary lipid compositions in model intestinal solution               
    Keisuke Matsuoka; Ebisawa Rie; Saori Yui; Chikako Honda; Kazutoyo Endo
    CHEMISTRY AND PHYSICS OF LIPIDS, Volume:165, Number:1, First page:7, Last page:14, Jan. 2012, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.chemphyslip.2011.10.004
    DOI ID:10.1016/j.chemphyslip.2011.10.004, ISSN:0009-3084, Web of Science ID:WOS:000299580000002
  • Biliary excretion of essential trace elements in rats under oxidative stress caused by selenium deficiency               
    Kosuke Yamasaki; Yasunobu Sakuma; Junya Sasaki; Ken-ichiro Matsumoto; Kazunori Anzai; Keisuke Matsuoka; Chikako Honda; Masamichi Tsukada; Kazutoyo Endo; Shuichi Enomoto
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Volume:401, Number:8, First page:2531, Last page:2538, Nov. 2011, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1007/s00216-011-5333-4
    DOI ID:10.1007/s00216-011-5333-4, ISSN:1618-2642, Web of Science ID:WOS:000295508600021
  • Effect of double quaternary ammonium groups on micelle formation of partially fluorinated surfactant               
    Keisuke Matsuoka; Nagisa Chiba; Tomokazu Yoshimura; Emi Takeuchi
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, Volume:356, Number:2, First page:624, Last page:629, Apr. 2011, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.jcis.2011.01.030
    DOI ID:10.1016/j.jcis.2011.01.030, ISSN:0021-9797, Web of Science ID:WOS:000288527800032
  • Competitive solubilization of cholesterol and six species of sterol/stanol in bile salt micelles               
    Keisuke Matsuoka; Eriko Kajimoto; Maho Horiuchi; Chikako Honda; Kazutoyo Endo
    CHEMISTRY AND PHYSICS OF LIPIDS, Volume:163, Number:4-5, First page:397, Last page:402, May 2010, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.chemphyslip.2010.03.006
    DOI ID:10.1016/j.chemphyslip.2010.03.006, ISSN:0009-3084, eISSN:1873-2941, Web of Science ID:WOS:000278169400010
  • Micellization of bile salts and solubilization into the micelles               
    Matsuoka, Keisuke; Lee, Jungno; Moroi, Yoshikiyo
    Journal of Surface Science and Technology, Volume:26, First page:105, Last page:136, 2010, [Reviewed]
    English, Scientific journal
  • Surface properties and aggregate morphology of partially fluorinated carboxylate-type anionic gemini surfactants               
    Tomokazu Yoshimura; Miri Bong; Keisuke Matsuoka; Chikako Honda; Kazutoyo Endo
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, Volume:339, Number:1, First page:230, Last page:235, Nov. 2009, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.jcis.2009.07.054
    DOI ID:10.1016/j.jcis.2009.07.054, ISSN:0021-9797, Web of Science ID:WOS:000272262900029
  • Solubilization of n-alkylbenzene and n-perfluoroalkylbenzene in hydrogenated and fluorinated surfactants micelles               
    Keisuke Matsuoka; Emi Takeuchi; Megumi Takahashi; Satomi Kitsugi; Chikako Honda; Kazutoyo Endo
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, Volume:333, Number:2, First page:641, Last page:645, May 2009, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.jcis.2009.02.009
    DOI ID:10.1016/j.jcis.2009.02.009, ISSN:0021-9797, Web of Science ID:WOS:000265121500029
  • Dynamics of redox related elements (Fe, Co, Zn, and Se) and oxidative stress caused by Se-deficiency in rats               
    Y. Sakuma; K. Matsuoka; C. Honda; K. Matsumoto; K. Endo
    JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, Volume:278, Number:3, First page:591, Last page:594, Dec. 2008, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1007/s10967-008-1011-1
    DOI ID:10.1007/s10967-008-1011-1, ISSN:0236-5731, Web of Science ID:WOS:000261262500011
  • Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles               
    Keisuke Matsuoka; Tomomi Nakazawa; Ai Nakamura; Chikako Honda; Kazutoyo Endo; Masamichi Tsukada
    CHEMISTRY AND PHYSICS OF LIPIDS, Volume:154, Number:2, First page:87, Last page:93, Aug. 2008, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.chemphyslip.2008.05.002
    DOI ID:10.1016/j.chemphyslip.2008.05.002, ISSN:0009-3084, eISSN:1873-2941, Web of Science ID:WOS:000258369200002
  • Nanocage aggregates composed of bilayer sheets               
    Keisuke Matsuoka; Tomokazu Yoshimura; Miri Bong; Chikako Honda; Kazutoyo Endo
    LANGMUIR, Volume:24, Number:11, First page:5676, Last page:5678, Jun. 2008, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1021/la800618v
    DOI ID:10.1021/la800618v, ISSN:0743-7463, Web of Science ID:WOS:000256232900010
  • Indomethacin solubilization induced shape transition in CnE7 (n=14,16) nonionic micelles               
    Shigeaki Ishii; Sho Ishikawa; Nozomi Mizuno; Keisuke Matsuoka; Chikako Honda; Kazutoyo Endo
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, Volume:317, Number:1, First page:115, Last page:120, Jan. 2008, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.jcis.2007.09.021
    DOI ID:10.1016/j.jcis.2007.09.021, ISSN:0021-9797, Web of Science ID:WOS:000251283100014
  • NMR study on solubilization of sterols and aromatic compounds in sodium taurodeoxycholate micelles               
    Keisuke Matsuoka; Shigeaki Ishii; Chikako Honda; Kazutoyo Endo; Akio Saito; Yoshikiyo Moroi; Osamu Shibata
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Volume:80, Number:12, First page:2334, Last page:2341, Dec. 2007, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1246/bcsj.80.2334
    DOI ID:10.1246/bcsj.80.2334, ISSN:0009-2673, eISSN:1348-0634, Web of Science ID:WOS:000252141000009
  • Molecular aggregates of partially fluorinated quaternary ammonium salt gemini surfactants               
    Keisuke Matsuoka; Tomokazu Yoshimura; Takashi Shikimoto; Juri Hamada; Mika Yamawaki; Chikako Honda; Kazutoyo Endo
    LANGMUIR, Volume:23, Number:22, First page:10990, Last page:10994, Oct. 2007, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1021/la701525c
    DOI ID:10.1021/la701525c, ISSN:0743-7463, Web of Science ID:WOS:000250228100023
  • Changes in the components of biliary and plasma lipids in selenium-deficient rats               
    Yasunobu Sakuma; Junya Sasaki; Aya Futami; Kousuke Yamasaki; Keisuke Matsuoka; Chikako Honda; Kazutoyo Endo; Masarnichi Tsukada
    CHEMISTRY AND PHYSICS OF LIPIDS, Volume:148, Number:2, First page:70, Last page:76, Aug. 2007, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.chemphyslip.2007.04.005
    DOI ID:10.1016/j.chemphyslip.2007.04.005, ISSN:0009-3084, Web of Science ID:WOS:000248433600003
  • Thermodynamic study on competitive solubilization of cholesterol and P-sitosterol in bile salt micelles               
    Keisuke Matsuoka; Takashi Hirosawa; Chikako Honda; Kazutoyo Endo; Yoshikiyo Moroi; Osamu Shibata
    CHEMISTRY AND PHYSICS OF LIPIDS, Volume:148, Number:1, First page:51, Last page:60, Jul. 2007, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.chemphyslip.2007.04.007
    DOI ID:10.1016/j.chemphyslip.2007.04.007, ISSN:0009-3084, Web of Science ID:WOS:000248174500003
  • Aggregate structure of N-(perfluoroalkylmethyl)-N,N,N-trimethylammonium chloride by transmission electron microscopy               
    Keisuke Matsuoka; Mariko Ishii; Aki Yonekawa; Chikako Honda; Kazutoyo Endo; Yoshikiyo Moroi; Yutaka Abe; Takamitsu Tamura
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Volume:80, Number:6, First page:1129, Last page:1131, Jun. 2007, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1246/bcsj.80.1129
    DOI ID:10.1246/bcsj.80.1129, ISSN:0009-2673, eISSN:1348-0634, Web of Science ID:WOS:000248256600011
  • Antibacterial activity of long-chain fatty alcohols against Staphylococcus aureus               
    Naoko Togashi; Akiko Shiraishi; Miki Nishizaka; Keisuke Matsuoka; Kazutoyo Endo; Hajime Hamashima; Yoshihiro Inoue
    MOLECULES, Volume:12, Number:2, First page:139, Last page:148, Feb. 2007, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.3390/12020139
    DOI ID:10.3390/12020139, ISSN:1420-3049, Web of Science ID:WOS:000244767600002
  • Micellar size, shape and counterion binding of N-(1,1-Dihydroperfluoroalkyl)-N,N,N-trimethylammonium chloride in aqueous solutions               
    Keisuke Matsuoka; Aki Yonekawa; Mariko Ishii; Chikako Honda; Kazutoyo Endo; Yoshikiyo Moroi; Yutaka Abe; Takamitsu Tamura
    COLLOID AND POLYMER SCIENCE, Volume:285, Number:3, First page:323, Last page:330, Dec. 2006, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1007/s00396-006-1574-8
    DOI ID:10.1007/s00396-006-1574-8, ISSN:0303-402X, Web of Science ID:WOS:000242146000008
  • Temperature dependence of pyrene fluorescence spectra in aqueous solutions of CnEm (C14E7, C16E7, and C16E6) nonionic surfactant micelles               
    Chikako Honda; Yumi Katsumata; Risa Yasutome; Sanae Yamazaki; Shigeaki Ishii; Keisuke Matsuoka; Kazutoyo Endo
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, Volume:182, Number:2, First page:151, Last page:157, Aug. 2006, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.jphotochem.2006.02.003
    DOI ID:10.1016/j.jphotochem.2006.02.003, ISSN:1010-6030, Web of Science ID:WOS:000239874600005
  • Micellization of conjugated chenodeoxy- and ursodeoxycholates and solubilization of cholesterol into their micelles: comparison with other four conjugated bile salts species               
    K Matsuoka; M Suzuki; C Honda; K Endo; Y Moroi
    CHEMISTRY AND PHYSICS OF LIPIDS, Volume:139, Number:1, First page:1, Last page:10, Jan. 2006, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.chemphyslip.2005.08.006
    DOI ID:10.1016/j.chemphyslip.2005.08.006, ISSN:0009-3084, PubMed ID:16256096, Web of Science ID:WOS:000234822000001
  • Spontaneous membrane fusion induced by chemical formation of ceramides in a lipid bilayer               
    Kunishima, Munetaka; Tokaji, Masafumi; Matsuoka, Keisuke; Nishida, Jin; Kanamori, Masanori; Hioki, Kazuhito; Tani, Shohei
    Journal of the American Chemical Society, Volume:128, Number:45, First page:14452, Last page:14453, 2006, [Reviewed]
    Scientific journal
    DOI:https://doi.org/10.1021/ja0652969
    DOI ID:10.1021/ja0652969, ISSN:0002-7863, ORCID:42933560, PubMed ID:17090016, Web of Science ID:WOS:000241857200018
  • Micelle formation and surface adsorption of octaethylene glycol monoalkyl ether (CnE8)               
    M Rusdi; Y Moroi; T Hlaing; K Matsuoka
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Volume:78, Number:4, First page:604, Last page:610, Apr. 2005
    English, Scientific journal
    DOI:https://doi.org/10.1246/bcsj.78.604
    DOI ID:10.1246/bcsj.78.604, ISSN:0009-2673, eISSN:1348-0634, SCOPUS ID:18744387421, Web of Science ID:WOS:000228912900006
  • Micelle formation and surface adsorption of octaethylene glycol monoalkyl ether (CnE8)               
    M Rusdi; Y Moroi; T Hlaing; K Matsuoka
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Volume:78, Number:4, First page:604, Last page:610, Apr. 2005, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1246/bcsj.78.604
    DOI ID:10.1246/bcsj.78.604, ISSN:0009-2673, eISSN:1348-0634, Web of Science ID:WOS:000228912900006
  • O/W emulsion of n-alkylbenzene/ionic surfactant/water systems               
    Y Doi; Y Kawashima; K Matsuoka; Y Moroi
    JOURNAL OF PHYSICAL CHEMISTRY B, Volume:108, Number:8, First page:2594, Last page:2599, Feb. 2004, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1021/jp0304879
    DOI ID:10.1021/jp0304879, ISSN:1520-6106, Web of Science ID:WOS:000189152000016
  • Characteristics of conjugate bile salt-phosphatidylcholine-cholesterol-water systems               
    K Matsuoka; M Maeda; Y Moroi
    COLLOIDS AND SURFACES B-BIOINTERFACES, Volume:33, Number:2, First page:101, Last page:109, Jan. 2004, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.colsurfb.2003.09.002
    DOI ID:10.1016/j.colsurfb.2003.09.002, ISSN:0927-7765, Web of Science ID:WOS:000188863300005
  • Micelle formation of sodium chenodeoxycholate and solubilization into the micelles: comparison with other unconjugated bile salts               
    R Ninomiya; K Matsuoka; Y Moroi
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Volume:1634, Number:3, First page:116, Last page:125, Nov. 2003, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/j.bbalip.2003.09.003
    DOI ID:10.1016/j.bbalip.2003.09.003, ISSN:1388-1981, Web of Science ID:WOS:000186987500007
  • Micelle formation of sodium chenodeoxycholate and solubilization into the micelles: comparison with other unconjugated bile salts.               
    Ninomiya R; Matsuoka K; Moroi Y
    Biochimica et biophysica acta, Volume:1634, Number:3, First page:116, Last page:125, Nov. 2003, [Reviewed]
    DOI:https://doi.org/10.1016/j.bbalip.2003.09.003
    DOI ID:10.1016/j.bbalip.2003.09.003, ISSN:0006-3002, PubMed ID:14643799
  • Micelle formation of sodium glyco- and taurocholates and sodium glyco- and taurodeoxycholates and solubilization of cholesterol into their micelles               
    K Matsuoka; M Maeda; Y Moroi
    COLLOIDS AND SURFACES B-BIOINTERFACES, Volume:32, Number:2, First page:87, Last page:95, Oct. 2003, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/S0927-7765(03)00148-6
    DOI ID:10.1016/S0927-7765(03)00148-6, ISSN:0927-7765, Web of Science ID:WOS:000185549100001
  • Micellization of fluorinated amphiphiles               
    K Matsuoka; Y Moroi
    CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, Volume:8, Number:3, First page:227, Last page:235, Aug. 2003, [Reviewed]
    English
    DOI:https://doi.org/10.1016/S1359-0294(03)00056-6
    DOI ID:10.1016/S1359-0294(03)00056-6, ISSN:1359-0294, Web of Science ID:WOS:000184757000004
  • Temperature effect on formation of sodium cholate micelles               
    H Sugioka; K Matsuoka; Y Moroi
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, Volume:259, Number:1, First page:156, Last page:162, Mar. 2003, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/S0021-9797(02)00191-1
    DOI ID:10.1016/S0021-9797(02)00191-1, ISSN:0021-9797, PubMed ID:12651144, Web of Science ID:WOS:000181864700017
  • Micelle formation of sodium deoxycholate and sodium ursodeoxycholate (Part 1)               
    K Matsuoka; Y Moroi
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Volume:1580, Number:2-3, First page:189, Last page:199, Feb. 2002, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/S1388-1981(01)00203-7
    DOI ID:10.1016/S1388-1981(01)00203-7, ISSN:1388-1981, PubMed ID:11880243, Web of Science ID:WOS:000174494600009
  • Solubilization of cholesterol and polycyclic aromatic compounds into sodium bile salt micelles (Part 2)               
    K Matsuoka; Y Kuranaga; Y Moroi
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Volume:1580, Number:2-3, First page:200, Last page:214, Feb. 2002, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1016/S1388-1981(01)00204-9
    DOI ID:10.1016/S1388-1981(01)00204-9, ISSN:1388-1981, PubMed ID:11880244, Web of Science ID:WOS:000174494600010
  • Micelle formation of n-decyltrimethylammonium perfluorocarboxylates               
    N Yoshida; K Matsuoka; Y Moroi
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, Volume:187, Number:2, First page:388, Last page:395, Mar. 1997, [Reviewed]
    English, Scientific journal
    DOI:https://doi.org/10.1006/jcis.1996.4691
    DOI ID:10.1006/jcis.1996.4691, ISSN:0021-9797, Web of Science ID:WOS:A1997WQ33200014
  • ELECTRIC-CONDUCTIVITY ANALYSIS OF MICELLAR SOLUTION OF SODIUM DODECYL-SULFATE               
    Y MOROI; K MATSUOKA
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Volume:67, Number:8, First page:2057, Last page:2061, Aug. 1994, [Reviewed]
    English, Scientific journal
    ISSN:0009-2673, eISSN:1348-0634, Web of Science ID:WOS:A1994PG24200010
  • Thermodynamics of micelle formation of 1-dodecanesulfonic acid
    Keisuke Matsuoka; Yoshikiyo Moroi; Masahiko Saito
    Journal of Physical Chemistry, Volume:97, First page:13006, Last page:13010, Jan. 1993, [Reviewed]
    The critical micelle concentrations (cmc's) of 1-dodecanesulfonic acid in aqueous solution were precisely determined over the temperature range 278.2-323.2 K by an electrical conductivity method. The degrees of counterion binding to micelle were obtained over the above temperature range by cmc change with total counterion concentration. Molecular weights of micelles were determined by static light scattering. Activity change of the counterion H+ with total surfactant concentration was estimated by pH values of the solutions. The mass action model was applied to the micelle formation in order to enumerate the three micellization parameters from these values: micellization constant, micelle aggregation number, and the number of counterions per micelle. Thermodynamic parameters (ΔG°, ΔH°, ΔS°) of micelle formation were then calculated from the temperature change of these parameters. At lower temperatures, the micellization was found to be entropy-driven, while at higher temperatures it was enthalpy-driven. The micellization parameters also made it possible to evaluate the concentration change of every chemical species with total surfactant concentration, and the total conductivity was divided into the contribution of each chemical species. The activity coefficient of the counterion started to increase above the cmc due to its excess concentration in the intermicellar bulk phase. ? 1993 American Chemical Society.
    DOI:https://doi.org/10.1021/j100151a059
    DOI ID:10.1021/j100151a059
■ MISC
  • 泡沫分離による水溶液からの物質の除去—Removal of Materials from Aqueous Solution by Foam Separation—特集 泡の最新研究動向 : 構造・性能・機能の応用               
    松岡 圭介
    Volume:24, Number:7, First page:305, Last page:310, Jul. 2024
    Japanese
    ISSN:1345-8949, CiNii Books ID:AA11503417
  • 分析化学と材料物性 表面張力と界面張力
    松岡圭介
    ぶんせき, Number:3, First page:97‐98, 05 Mar. 2016
    Japanese
    ISSN:0386-2178, J-Global ID:201602207697098950
  • 植物ステロール/スタノールによるコレステロールの吸収抑制機構に関する研究               
    松岡圭介
    オレオサイエンス, Volume:11, Number:4, First page:119, Last page:125, 01 Apr. 2011
    Japanese
    DOI ID:10.5650/oleoscience.11.119, ISSN:1345-8949, J-Global ID:201102289084616354, CiNii Articles ID:40018765807, CiNii Books ID:AA11503417
  • マルチトレーサー法と放射化分析法によるSe欠乏ラット胆汁中の微量元素の動態の解析               
    山崎 公輔; 塚田 正道; 遠藤 和豊; 本田 智香子; 松岡 圭介; 松本 謙一郎; 安西 和紀; 榎本 秀一
    Volume:130年会, Number:4, First page:127, Last page:127, Mar. 2010
    Japanese
    ISSN:0918-9823, 医中誌Web ID:2011238918
  • 胆汁酸塩ミセルへのコレステロール及び植物ステロール/スタノールの競争的可溶化
    松岡圭介
    Colloid & Interface Communication, Volume:34, Number:2, First page:14, Last page:15, 10 May 2009
    Japanese
    J-Global ID:201002220477410963
  • Mouse Abcg5/Abcg8発現系におけるステロール輸送に関するin vitro機能解析
    前田和哉; 浅野静佳; 杉山雄一; 高田龍平; 松岡圭介
    薬理と治療, Volume:34, Number:Suppl.2, First page:S.101-S.105, 15 Dec. 2006
    Japanese
    ISSN:0386-3603, J-Global ID:200902225116084981
  • 胆汁酸塩のミセル形成とミセルヘの可溶化(コレステロール及びホスファチジルコリン)―その2               
    松岡圭介; 師井義清
    表面(表面談話会・コロイド懇話会), Volume:41, Number:10, First page:357, Last page:369, 01 Oct. 2003
    Japanese
    ISSN:0367-648X, J-Global ID:200902264003962139, CiNii Articles ID:40006262202, CiNii Books ID:AN00211091
  • 胆汁酸塩のミセル形成とミセルへの可溶化               
    松岡圭介; 師井義清
    表面(表面談話会・コロイド懇話会), Volume:41, Number:7, First page:242, Last page:252, 01 Jul. 2003
    Japanese
    ISSN:0367-648X, J-Global ID:200902203529972024, CiNii Articles ID:40006015858, CiNii Books ID:AN00211091
■ Affiliated academic society
  • THE CHEMICAL SOCIETY OF JAPAN
  • JAPAN OIL CHEMISTS' SOCIETY
■ Research projects
  • Metal removal by novel foam separation method in which ionic polymers are adsorbed on vesicle carriers               
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), 01 Apr. 2022 - 31 Mar. 2025
    Saitama University
    Grant amount(Total):3380000, Direct funding:2600000, Indirect funding:780000
    Grant number:22K05185
  • Establishment of foam separation method for removal of radioactive metals               
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), 01 Apr. 2016 - 31 Mar. 2019
    MATSUOKA Keisuke, Saitama University
    Grant amount(Total):4290000, Direct funding:3300000, Indirect funding:990000
    Foam separation could be used to remove a series of alkali metals and alkali earth metals from aqueous solutions based on electrostatic interactions between the anionic surfactant and metals. The most suitable concentration of the surfactant for which the alkali ions were selectively adsorbed was less than the CMC. The microbubble generator apparatus used in this study was effective in removing the alkali metals. The order of removal rate of the alkali metal was almost Li < K < Rb < Cs for the sodium dodecylsulfate surfactant system. On the other hand, the order of removal rate of the alkali earth metal was almost Mg < Ca < Sr for the sodium decylsulfate surfactant system. The order is lined up atomic number. The first order of removal rate constants with crystal ion radius were showed linear relationships in respective series. This method may be applied in the purification of the contaminated water from nuclear power plants and in industrial drainage.
    Grant number:16K00582
  • Possibility of the glycyrrhizic acid as emulsifier for drug and the application to absorption inhibitor of cholesterol               
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), 01 Apr. 2013 - 31 Mar. 2016
    MATSUOKA Keisuke, Saitama University
    Grant amount(Total):4290000, Direct funding:3300000, Indirect funding:990000
    The glycyrrhizin acid has two carboxylic groups at double glucuronic acids and one carboxylic group on the top of molecule as the hydrophilic part. Therefore, the polyvalent weak acid had a great influence on the surface and aggregate properties depending on the pH of the buffer solutions. The aqueous solubility of glycyrrhizin acid was quite low in the lower pH range. The pH range for micelle formation was quite narrow, from pH 5 to 6. Glycyrrhizic acid forms rod-like micelles.The existence of this aggregate highlights the potential applications of glycyrrhizic acid as an emulsifier and solubilization agent. Glycyrrhizin acid exists as monomer state at pH > 7. Therefore, it is necessary to pay attention to the pH of the solution when this biosurfactant is used as an emulsifier or solubilizer in the practical fields. In future, the aggregation structure based on the specific molecular structure will be examined using similar compounds, glycyrrhetic acid, 3-O-glucuronide.
    Grant number:25460043
  • Investigation into mechanism of inhibitive cholesterol absorption by plant sterols and the novel method               
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), 2009 - 2011
    MATSUOKA Keisuke, Showa Pharmaceutical University
    Grant amount(Total):4030000, Direct funding:3100000, Indirect funding:930000
    The mechanism of cholesterol lowering by the addition of several kinds of plant sterols/sterols was investigated in model intestinal solution. Slight differences in the molecular structures of a category of sterol/stanol species affect the solubility of cholesterol in a model intestinal solution. The results of competitive solubilization revealed that cholestanol has the largest cholesterol-lowering effect, decreasing cholesterol solubility to 35% of that in a single solubilizate system. The cholesterol-lowering effect increase in the order ofGrant number:21790043
  • OXIDATIVE STRESS BY SE-DEFICIENCY AND DYNAMICS OF BIOTRACE ELEMENTS               
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), 2005 - 2007
    ENDO Kazutoyo; HONDA Chikako; MATSUOKA Keisuke; ENOMOTO Shuichi, Showa Pharmaceutical University
    Grant amount(Total):3680000, Direct funding:3500000, Indirect funding:180000
    1) In vivo free radical reactions in rat liver as a result of exposure to low-dose β-radiation was evaluated with electron paramagnetic resonance (EPR) spectroscopy by monitoring the reduction of the nitroxyl spin probe after intravenous administration. Results suggest that under low levels of tissue oxygen, exposure to β-rays results in nitroxyl signal loss, which may be mediated by free radical dependent pathways.
    2) Biochemical data of AST, ALT, and BUN for the plasma fraction of the rat bloods, and the concentration of vitamin C and vitamin E were measured in the liver homogenates. The relationships among the biotrace elements and the biochemical data were compared, and the indices for oxidative stress caused by selenium deficiency were discussed in terms of reactive oxygen species (ROS) , and antioxidants in the organism.
    3) Free radical-reducing activity and membrane fluidity of liver microsomes from Se-deficient (SeD) Wistar rats were examined by EPR spin label method using nitroxyl-labeled stearic acids. SeD induced the liver microsomal cytochrome P 450 activity ; the nitroxyl spin probes are substrates for reduction-relating cytochrome P 450. The reduction rate of nitroxyl radical at shallow depth in membranes was increased.
    4) Although the oxidative stress caused Fe accumulation in the liver, the Fe concentration in bile of the SeD rat was almost the same as that in the control rats. Due to the trapping of reactive oxygen species, only bilirubin concentrations in the bile and plasma were decreased in the SeD group, when compared with those in the control group. Measurement of bilirubin concentration may be used as a supplemental oxidative stress marker.
    5) Dynamics of redox relating biotrace elements, selenium, iron, and zinc in liver, kidney, and spleen of selenium deficient Wistar male rats in a series of feeding period (from 0 to 8 weeks) were studied using instrumental neutron activation analysis. The results were compared with those of aspartate aminotransferase (AST) , alanine aminotransferase (ALT) , and blood urea nitrogen (BUN) for the plasma fraction of the rat bloods.
    Grant number:17590040
■ Industrial Property Rights
  • 横型高耐圧トランジスタ               
    Patent right
    J-Global ID:200903061428636966
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